COMMENT The mechanisms underlying the disruption of the choroid plexus in aging and age-related neurodegenerative diseases remain relatively underexplored. In this insightful study, Chen et al. provide compelling evidence that macrophage activity plays a crucial

Tord Labuda

Alzinova AB
, Sweden

Stefan Pierrou

Alzinova AB
, Sweden

PAPER Alldred MJ, Ibrahim KW, Pidikiti H, Lee SH, Heguy A, Chiosis G, Mufson EJ, Stutzmann GE, Ginsberg SD

Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

Front Mol Neurosci. 2025;18:1546375. Epub 2025 Feb 26 PubMed.

PAPER Sohur US, Gray DL, Duvvuri S, Zhang Y, Thayer K, Feng G

Phase 1 Parkinson's Disease Studies Show the Dopamine D1/D5 Agonist PF-06649751 is Safe and Well Tolerated.

Neurol Ther. 2018 Dec;7(2):307-319. Epub 2018 Oct 25 PubMed.

PAPER Gray DL, Allen JA, Mente S, O'Connor RE, DeMarco GJ, Efremov I, Tierney P, Volfson D, Davoren J, Guilmette E, Salafia M, Kozak R, Ehlers MD

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

Nat Commun. 2018 Feb 14;9(1):674. PubMed.

Richard Ransohoff on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT This paper focuses useful attention on the choroid plexus as a potential contributor to brain aging. The approach taken was to evaluate tight junctions of the CP epithelium, identifying claudin-1 (product of the CLDN1 gene) as declining in abundance with

PAPER Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

Sci Transl Med. 2023 Jan 18;15(679):eabq6288. Epub 2023 Jan 18 PubMed.

Fanny Ehret

, Germany

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Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold.

The Correlation Between RIN3 Gene Methylation and Cognitive Impairment in Parkinson's Disease.

Factors Associated With Alzheimer's Dementia Diagnosis and Survival in Down Syndrome.

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.

Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease.

Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [125I]Radioiodinated DYRK1A Inhibitor.

Aurore Delvenne on With Age, Macrophages Chew up the Blood-CSF Barrier