ApoE4 Gene May Be Risk Factor in Only a Subset of Cases

RESEARCH NEWS 1997-02-21 Research News A new study reports that the ApoE4 gene, previously reported to be over-represented among patients with late onset Alzheimer's disease, appears to be a risk factor only among patients who developed the disease before age 70. The study e

PAPER Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.

Nat Med. 2015 Aug;21(8):932-7. Epub 2015 Jul 6 PubMed.

PAPER Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis.

J Neuroinflammation. 2014 Jan 8;11:3. PubMed.

PAPER Billioti de Gage S, Moride Y, Ducruet T, Kurth T, Verdoux H, Tournier M, Pariente A, Bégaud B

Benzodiazepine use and risk of Alzheimer's disease: case-control study.

BMJ. 2014 Sep 9;349:g5205. PubMed.

PAPER Xie L, Li W, Winters A, Yuan F, Jin K, Yang S

Methylene blue induces macroautophagy through 5' adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation.

Front Cell Neurosci. 2013 Jan 1;7:56. Epub 2013 May 3 PubMed.

PAPER Kim JA, Yun HM, Jin P, Lee HP, Han JY, Udumula V, Moon DC, Han SB, Oh KW, Ham YW, Jung HS, Song HS, Hong JT

Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells.

Neuropharmacology. 2014 Apr;79:476-87. Epub 2013 Jul 23 PubMed.

PSEN1 A434C

MUTATIONS PSEN1 73219185_73219186 GRCh38/hg38 GC TG 73685893_73685894 GRCh37/hg19 GC TG Exon 12 Point, Double Coding Increased Aβ42 and decreased Aβ40 production in vitro, resulting in an increased Aβ42/Aβ40 ratio. Numerous diffuse plaques and neuritic plaques with

PAPER Ries V, Oertel WH, Höglinger GU

Mitochondrial dysfunction as a therapeutic target in progressive supranuclear palsy.

J Mol Neurosci. 2011 Nov 1;45(3):684-9. Epub 2011 Jul 27 PubMed.

PAPER Shi Z, Hayashi YK, Mitsuhashi S, Goto K, Kaneda D, Choi YC, Toyoda C, Hieda S, Kamiyama T, Sato H, Wada M, Noguchi S, Nonaka I, Nishino I

Characterization of the Asian myopathy patients with VCP mutations.

Eur J Neurol. 2012 Mar;19(3):501-9. Epub 2011 Oct 31 PubMed.

PAPER Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.

Lancet Neurol. 2010 Dec;9(12):1164-72. PubMed.

PAPER Zinman L, Liu HN, Sato C, Wakutani Y, Marvelle AF, Moreno D, Morrison KE, Mohlke KL, Bilbao J, Robertson J, Rogaeva E

A mechanism for low penetrance in an ALS family with a novel SOD1 deletion.

Neurology. 2009 Mar 31;72(13):1153-9. PubMed.

PAPER Borroni B, Bonvicini C, Alberici A, Buratti E, Agosti C, Archetti S, Papetti A, Stuani C, Di Luca M, Gennarelli M, Padovani A

Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease.

Hum Mutat. 2009 Nov;30(11):E974-83. PubMed.

PAPER Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J

A synergistic small-molecule combination directly eradicates diverse prion strain structures.

Nat Chem Biol. 2009 Dec;5(12):936-46. PubMed.

PAPER Takahashi Y, Seki N, Ishiura H, Mitsui J, Matsukawa T, Kishino A, Onodera O, Aoki M, Shimozawa N, Murayama S, Itoyama Y, Suzuki Y, Sobue G, Nishizawa M, Goto J, Tsuji S

Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosis.

Arch Neurol. 2008 Oct;65(10):1326-32. PubMed.

PAPER Kimonis VE, Fulchiero E, Vesa J, Watts G

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder.

Biochim Biophys Acta. 2008 Dec;1782(12):744-8. Epub 2008 Sep 18 PubMed.