PAPER T S S, N K

Taylor-dingo optimized RP-net for segmentation toward Alzheimer's disease detection and classification using deep learning.

Comput Biol Chem. 2025 Jun;116:108359. Epub 2025 Feb 13 PubMed.

PAPER Wu M, Zhang R, Fu P, Mei Y

Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer's disease.

Neuroscience. 2025 Mar 27;570:132-151. Epub 2025 Feb 20 PubMed.

PAPER Rahman AU, Ali S, Saqia B, Halim Z, Al-Khasawneh MA, AlHammadi DA, Khan MZ, Ullah I, Alharbi M

Alzheimer's disease prediction using 3D-CNNs: Intelligent processing of neuroimaging data.

SLAS Technol. 2025 Mar 6;32:100265. Epub 2025 Mar 6 PubMed.

PAPER Singh-Reilly N, Pham NT, Graff-Radford J, Machulda MM, Spychalla AJ, Senjem ML, Petersen RC, Lowe VJ, Boeve BF, Jack CR Jr, Josephs KA, Kantarci K, Whitwell JL

White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy.

Neurobiol Aging. 2025 Mar 3;150:44-52. Epub 2025 Mar 3 PubMed.

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Novel mRNA isoforms in human microglia refine genetic associations with neurodegeneration.

Nat Genet. 2025 Mar;57(3):492-493. PubMed.

Leon French on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT I commend Grandke et al. for highlighting that their strongest pathway-level signal, "SRP-dependent cotranslational protein targeting to membrane," aligns with the gingipain hypothesis. This pathway primarily comprises ribosomal proteins, e.g. R

PAPER Avey DR, Ng B, Vialle RA, Kearns NA, Lopes Kd, Iatrou A, Tissera SD, Vyas H, Saunders DM, Flood DJ, Xu J, Tasaki S, Gaiteri C, Bennett DA, Wang Y

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics

bioRxiv2024.09.05.611566 .

PSEN1 Q223K

MUTATIONS PSEN1 73659470 GRCh37/hg19 rs1898776259 C A 73192762 GRCh38/hg38 rs1898776259 C A Exon 7 Coding Increased Aβ42 levels and the Aβ42/Aβ40 ratio in cells. Unknown. Q223K Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed information on

PSEN1 W165L

MUTATIONS PSEN1 73653574 GRCh37/hg19 rs1898534725 G T 73186866 GRCh38/hg38 G T Exon 6 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 28.3). Unknown. W165L Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed info

Yizhou A. Liu

Washington University in St Louis School of Medicine
United States

PAPER Saikusa K, Kinumi T, Kato M

Development of amyloid β (1-42) certified reference material NMIJ CRM 6210-a.

Anal Bioanal Chem. 2025 Mar 5; Epub 2025 Mar 5 PubMed.

PAPER Limone A, Di Napoli C, Napolitano F, Imbò B, Minopoli G, Bagnoli S, Izzo A, Paladino S, Nacmias B, De Matteis MA, Montuori N, Lavecchia A, Sarnataro D

Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer's disease.

Biochim Biophys Acta Mol Basis Dis. 2025 Mar 2;1871(5):167753. Epub 2025 Mar 2 PubMed.

PAPER Zhang Z, Huang G, Gupta S, Sargent E, Tang H, Ding F

Determinants for Substoichiometric Inhibition of IAPP and Aβ Amyloid Aggregations by Bri2 BRICHOS.

ACS Chem Neurosci. 2025 Mar 4; Epub 2025 Mar 4 PubMed.

PAPER Kshirsagar S, Islam MA, Reddy AP, Reddy PH

Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars.

J Alzheimers Dis Rep. 2025;9:25424823241310716. Epub 2025 Jan 15 PubMed.

PAPER Liu JY, Tan CY, Luo L, Yin X

Gut microbiota may affect Alzheimer's disease through synaptic function mediated by CAMs pathway: A study combining Mendelian randomization and bioinformatics.

J Alzheimers Dis Rep. 2025;9:25424823241310719. Epub 2025 Jan 13 PubMed.