Walter J. Lukiw on Popcorn Plaque? Alzheimer Disease Is Slow, Yet Plaque Growth Is Fast

COMMENT Rapid Plaque Growth and Positive Cooperative Assembly Amyloid-β peptides constitute an intriguing class of molecules that self-assemble into stable, ordered structures, and their formation is reminiscent of the natural phenomenon of positive cooperative a

PAPER Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G

Allosteric cooperativity in protein kinase A.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):506-11. PubMed.

PAPER Courjean O, Chevreux G, Perret E, Morel A, Sanglier S, Potier N, Engel J, Van Dorsselaer A, Feracci H

Modulation of E-cadherin monomer folding by cooperative binding of calcium ions.

Biochemistry. 2008 Feb 26;47(8):2339-49. PubMed.

Donna M. Wilcock on Popcorn Plaque? Alzheimer Disease Is Slow, Yet Plaque Growth Is Fast

COMMENT Meyer-Luehmann and colleagues provide new insights into the temporal sequence of events surrounding amyloid plaque formation and the brain’s cellular responses to this formation. It is exciting to see that the rapid formation of plaques that had been pred

PAPER Shorter J, Lindquist S

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities.

Mol Cell. 2006 Aug 4;23(3):425-38. PubMed.

Axonal Transport Not Bothered by Tau Elevation In Vivo

RESEARCH NEWS 2008-02-14 Research News Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function and axonal transport. This hypothesis re

Required Reading—InteracTomes for AD, Aging, APP

RESEARCH NEWS 2008-02-14 Research News Fundamental knowledge gaps in Alzheimer disease research include a clear grasp of the normal role of the amyloid precursor protein (APP), and the molecular basis for the increased risk for AD as people age. Two recent papers took a systems a

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Samuel Muk

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Korea, Republic of

PAPER Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

Dev Cell. 2008 Feb;14(2):193-204. PubMed.

PAPER Soto C, Estrada LD

Protein misfolding and neurodegeneration.

Arch Neurol. 2008 Feb;65(2):184-9. PubMed.

PAPER Molina-Porcel L, Lladó A, Rey MJ, Molinuevo JL, Martinez-Lage M, Esteve FX, Ferrer I, Tolosa E, Blesa R

Clinical and pathological heterogeneity of neuronal intermediate filament inclusion disease.

Arch Neurol. 2008 Feb;65(2):272-5. PubMed.

PAPER Williams DR, Lees AJ, Wherrett JR, Steele JC

J. Clifford Richardson and 50 years of progressive supranuclear palsy.

Neurology. 2008 Feb 12;70(7):566-73. PubMed.

PAPER Holmøy T

T cells in amyotrophic lateral sclerosis.

Eur J Neurol. 2008 Apr;15(4):360-6. PubMed.

PAPER Benchoua A, Trioulier Y, Diguet E, Malgorn C, Gaillard MC, Dufour N, Elalouf JM, Krajewski S, Hantraye P, Déglon N, Brouillet E

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

Hum Mol Genet. 2008 May 15;17(10):1446-56. PubMed.