Steven Smith on Cryo-EM Unveils Distinct Aβ42 Fibril Structures for Sporadic, Familial AD

COMMENT For me, one of the still largely unanswered questions in the Alzheimer’s field is how the addition of two amino acids at the C-terminus of the Aβ peptide results in such a dramatic difference in the progression of AD. Aβ42 predominates in the parenchymal