Jacob George on In Mice, TREM2 Antibody Mobilizes Microglia, Yet Worsens Tangles
COMMENT The paper by Jain et al. adds an important piece to the complex puzzle of the interaction of TREM2 with microglia in the context of Aβ-associated tau seeding. The authors found, apparently counterintuitively, that TREM2 chronic agonism with a monoclonal a