Fernanda De Felice on Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
COMMENT This is a beautiful study that adds insight into the neuroprotective mechanisms of irisin in Alzheimer’s experimental models. In my opinion, the main takeaway of this study is that irisin triggers the release of neprilysin by binding integrins on astrocyt