6 RESULTS
COMMENT This comprehensive work extends previous work describing the critical role of cellular prion protein (PrP) as a member of the multiprotein Aβ oligomer receptor complex pioneered by Strittmatter and colleagues (Smith et al., 2019). As in previous published
COMMENT This paper is a much-needed quantitative examination of which proteins are necessary and sufficient to constitute Aβ 42 oligomer receptors. Oligomers as ligands Beginning more than 20 years ago (Lambert et al., 1998), Aβ42 oligomers are thought to be resp
COMMENT It is exciting to see the research community pursue anti-oligomer drug discovery and follow up on the original findings that LilrB2 is part of the oligomer receptor complex. It is a reflection of the renewed interest in the Aβ oligomer hypothesis and the
COMMENT These results presented at AAIC are exciting and have major implications for the AD therapeutics field. The authors used a previously published sensitive immunoassay capable of detecting Aβ oligomers in human CSF samples (Yang et al., 2015) to measure CSF
COMMENT Dale was a true pioneer, and one of the bravest industry scientists in the field. He will be sorely missed. scatalano_2 0
COMMENT This is a very important manuscript demonstrating that Aβ oligomers bind to and adversely affect a molecule critical for normal learning and memory, adding to the evidence that Alzheimer’s begins and persists as a synaptic plasticity disease. It was disco
