7 RESULTS
COMMENT This study is a fascinating deep dive into the effects of the X chromosome itself on vulnerability/resilience factors associated with AD. Lots of interest has been focused on the dichotomous indicator of biological sex and its impact on risk in recent pap
COMMENT I find this paper very exciting for a few reasons: Rodent models of enriched environments have long been explored as moderators of neurodegenerative disorders (Nithianantharajah and Hannan, 2006), The notion of cognitive reserve was, until recently, large
COMMENT This is a very interesting paper that has attempted to base amyloid staging on both CSF and PET biomarkers, which is unlike the previous approaches (e.g. Grothe et al., 2017). In this current approach, Niklas Mattsson and colleagues focused on applying th
COMMENT This study by Gilsanz and colleagues examines the question of whether length of exposure to endogenous estrogen (here, measured with proxies of age at menarche, age at menopause, and length of reproductive period) is protective for risk of progression to
COMMENT Dr. Villeneuve and colleagues provide an interesting take to assessment of APOE and sex effects on amyloid levels in clinically normal adults. Similar to findings presented in ADAD participants, the authors calculated an “estimated year of onset” for all
COMMENT After having read the manuscript, I am struck (again!) by the powerful predictive effect of age and ApoE4 on the likelihood of high amyloid burden in clinically normal (CN) older adults. Time and again this has been shown, however, it is interesting to se
COMMENT The approach of using CSF and PET to identify earlier stages of β-amyloidosis is quite interesting. Understanding where individuals are in the time course of disease is very difficult, particularly in preclinical stages, and the dual CSF/PET Aβ approach t
