Arnon Rosenthal, Ilaria Tassi, David Wang on In Mice, TREM2 Antibody Mobilizes Microglia, Yet Worsens Tangles
COMMENT The results from Dr. Holtzman’s group add to a growing literature on the complex, confusing, and often contradictory reported effects of TREM2 on amyloid and tau pathology in animal models. For example, Dr. Holtzman’s group had previously shown that cross