14 RESULTS
COMMENT Zhang et al. identified one target, human astrocyte-specific protein, TMEM164, which is suppressed in major neurodegenerative diseases including AD, PD, HD, MS, ALS, and FTLD patient brains through unbiased screening of overlapping molecules among these n
COMMENT This selective panel of 48 CSF protein study, found from deep discovery-based proteomics in AD patients defined by Aβ42, tTau, and pTau181 difference compared to control individuals, gives novel insights on biological, cellular process of current biomarke
COMMENT This very interesting study focuses on human CSF functional lipoproteins by identifying novel proteins and networks specific to CSF that are involved in multiple CNS diseases. Especially novel is the experimental design of lipid size-based isolation, foll
COMMENT Wyss-Coray and colleagues have identified a key regulator of lipid droplet (LD) biogenesis, ASCL1, activated specifically in microglia and in APOE4 human AD brain, then followed by triacylglycerol (TAG) synthesis and lipid droplet (LD) accumulation. In vi
COMMENT This ADAD CSF proteomic study is an asset to the AD community as it’s based on a collection of samples over the course of six decades. The authors showed changes in proteins from CSF associated with biomarker and pathological changes of AD. Especially pro
COMMENT You et al. used postmortem AD brain single nuclear RNA-Seq and identified one unique microglia signature that is functionally bidirectional by GWAS variants: an “interferon” cluster found in protective MS4A variant carriers, and a “chemokine” cluster in r
COMMENT Studies on tauopathy, especially those of MAPT mutations, have mainly focused on neurons, since MAPT is expressed in these cells and is known to dysregulate them. This study, using human organoids composed of various neurons and glia, comes from an intere
COMMENT Levey, Seyfried, and colleagues’ proteomic studies tell us that matrisome and cell-extracellular matrix (ECM) interaction modules are significantly upregulated in early stages of Alzheimer’s disease when amyloid and tau have accumulated, and that then pos
COMMENT Pluvinage et al. brought attention to Siglecs in brain function and neurodegeneration (Siddiqui et al., 2019). The Siglecs are mostly expressed in microglia regulating neuroinflammation, but some are present on oligodendrocytes involved in myelination. Si
COMMENT Shi et al. have shown that reducing the extracellular ApoE level by increasing LDLR in microglia potentially increases the intracellular lysosomal clearance program and suppresses tau-mediated neurodegeneration in the P301S mouse model. Here I discuss sev
COMMENT Safiyan, Besson-Girard, Gokce, Simons et al. identified white-matter-associated microglia named WAMs, which are an aging-specific microglial population. WAMs handle phagocytosis of demyelinating cellular debris, contributing to efferocytosis of apoptotic
COMMENT The Grutzendler group visualized spatiotemporal resolution of efferocytosis including sensing, engulfing and digesting the neuronal corpse by microglia and astrocytes by photochemically and virally induced single-cell-targeted ablation of neurons in the l
COMMENT Konttinen et al. have developed another microglia protocol based on human iPSC-derived primitive (but not definitive) erythromyeloid progenitors induced by hypoxia. The protocol is similar to but slightly simpler than that described by Abud and colleagues
COMMENT This is an interesting study that reminds me of Alois Alzheimer’s drawing of Nile red staining, which reveals intracellular lipid droplets (LD) in cells (potentially microglia) around plaques in AD patient brain. Here, Marschallinger and colleagues identi
