Ashok Shetty on Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
COMMENT In this study, the authors investigated how irisin could affect Aβ pathology in Alzheimer’s disease. They report that irisin treatment causes a reduction in Aβ pathology by stimulating increased neprilysin release from astrocytes. Additional analysis reve