5 RESULTS
COMMENT Imaging technologies have advanced so much over the last 10-15 years and our knowledge of how different cell types interact with one another in the brain —within living animals—has sharply increased during this time. This is no coincidence. Along this lin
COMMENT Historically, neurodegeneration research has been dominated by a neuron-centric focus. This has changed somewhat with the increasing recognition that glial cells mediate numerous protective and detrimental immune/inflammatory processes found in most neuro
COMMENT Calcineurin is increasingly recognized for its important roles in brain aging and age-related neurodegenerative diseases. Several recent studies have shown that neural calcineurin signaling is augmented in mouse models of Alzheimer’s disease (AD) (e.g., 1
COMMENT This elegant manuscript by Cruchaga et al. reveals that CSF phospho-tau levels and the rate of disease progression in AD subjects are strongly correlated to the presence of SNPs in the regulatory B subunit of calcineurin, a Ca 2+ /calmodulin-dependent pro
COMMENT The connection between DSCR1 and calcineurin/NFAT signaling with AD is indeed interesting. It’s clear that NFATs help increase DSCR1 expression in several different cell types (e.g., 1,2). Elevated DSCR1 levels in AD tissue are therefore consistent with r
