7 RESULTS
COMMENT The hallmarks of AD pathology are neurodegeneration associated with tau and Aβ pathologies. Studies in cultured cells and animal models reported over many years have indicated that each one of these three lesions can lead to one of the other two, creating
COMMENT It is hard to believe that John has passed away. John was a highly accomplished neurodegenerative diseases researcher. His work covered a wide area of research, which included neuropathology and pathophysiology of not only Alzheimer's disease but als
COMMENT This study clearly shows that CTE tau pathology is different from AD tau pathology and apparently each tauopathy has its own specific tau pathology signatures. I suspect that these different signatures of tau pathology in different tauopathies that show a
COMMENT This is a well-done study. Although the authors have not pointed it out, one very intriguing possible conclusion that can be drawn is that the Aβ drug trials, especially immunotherapies, continue to be negative because tau in AD brain is hyperphosphoryla
COMMENT This is an extensive study on post-translational modifications of tau by mass spectrometry analysis in wild-type (WT) and hAPP transgenic mouse brains. Most of the phosphorylation sites previously reported in postmortem normal human brains were also found
COMMENT Inhibition of Alzheimer Neurofibrillary Degeneration by Inhibition of O-GlcNAcase: A Sweet Approach With Some Bitter Hurdles Ahead The development of a potent O-GlcNAcase inhibitor and its ability to inhibit abnormal hyperphosphorylation of tau by Yuzwa e
COMMENT Alzheimer disease (AD), frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Guam parkinsonism dementia, cortical basal degeneration, dementia pugilistica, Pick’s disease, progressive supranuclear palsy, and tangle-only dementia, a
