15 RESULTS
COMMENT This article describes an interesting concept, where microglial microRNAs contribute to tau pathology (in neurons) in a sex-specific manner. Sex differences in onset and progression in Alzheimer’s disease and related tauopathy have been previously describ
COMMENT The study by Lehmann and colleagues provides a fascinating and unprecedented look at microRNA function in the brain. Typically, microRNAs function to regulate gene expression at the post-transcriptional level by targeting messenger RNAs, with known roles
COMMENT In the past months, much attention has been turned towards the involvement of miR-34 in brain health and disease. Here, the Bonini group provides compelling evidence that miR-34 is important for normal brain aging, with potential implications in neurodege
COMMENT In this somewhat “hard-core” transcriptomics study, the authors propose that human-specific gene expression changes that occur during brain development (in what the authors define as “type III” genes) are regulated mainly by transregulatory elements, and,
COMMENT Another player is added to the list of microRNAs involved in the regulation of APP: miR-101. To my knowledge, this is the fourth group reporting the indirect (1) and direct (2-4) regulation of APP expression by microRNAs. Others include let-7 and miR-20 f
COMMENT These two new studies highlight once again the importance of Dicer and microRNAs in brain function. Perhaps expectedly, the authors demonstrate in a convincing way that mammalian Dicer is required for oligodendrocyte differentiation and myelination. Here,
COMMENT The Olson group is a pioneer in the field of microRNA function in muscle cells. Here, the authors provide compelling evidence that miR-206, a skeletal muscle-specific “myomiR,” functions in a complex regulatory pathway to regulate ALS pathology in mice. T
COMMENT in-vitro models. I would like to comment on some issues with regards to mechanistic, physiological, and
COMMENT to comment on some of the salient observations reported by the authors. First, the authors show that
COMMENT The manuscript by Rademakers and colleagues provides evidence that increased binding of miR-659 to the 3’UTR of the GRN gene could underlie an important risk for TDP-43-positive frontotemporal dementia (FTLD-U). These data bring strong clinical support fo
COMMENT This is an interesting follow-up study from Lukiw’s group on the possible role of microRNAs in AD. Here, the authors identify a novel regulatory pathway (NFκB > miR-146a > complement factor H) potentially involved in the inflammation response in AD
COMMENT Non-coding RNAs are once again brought to the attention of the AD field. Now, intriguing work by Faghihi and coworkers reveal an unexpected role for antisense RNA transcripts (transcripts from the opposite strand to the protein-coding, or sense, strand) i
COMMENT It’s fascinating to see that microRNAs are slowly but surely making their mark in neurobiology. This is very nice work by Gary Wayman and colleagues, further characterizing a novel signaling pathway implicating miR-132 in neuronal function (Vo et al., 200
COMMENT The role of miRNAs in fundamental biology and more recently in neurodegenerative disorders is gaining popularity (1). Now, Peter Nelson’s group provides the first evidence that changes in miRNA expression could contribute to Alzheimer disease development.
COMMENT This interesting work by Zhang and colleagues contributes to the current debate in the field as to whether regulated intramembrane proteolysis of APP, like that of Notch, results in the activation of a biologically relevant nuclear signaling pathway. Here
