6 RESULTS
COMMENT Lin et al. have conducted a rigorous evaluation of three independent cohorts (German, UK Biobank, and ADSP longevity cohorts) to investigate key factors in longevity and resilience to age-related diseases including Alzheimer’s. Their results indicate sign
COMMENT We do plan to offer aducanumab to eligible patients at our center who request it, and who meet the characteristics of the participants in the Biogen trials, i.e., biomarker-confirmed Alzheimer’s disease without known contraindications. We have received a
COMMENT Zhao et al. report an elegant series of experiments that elucidate mechanisms through which ApoE4 can interfere with brain insulin signaling. Their finding that ApoE4 impairs neuronal insulin signaling by binding to the insulin receptor, accelerating its
COMMENT As noted in this interesting article, I think the approach of supplying alternate forms of bioenergetic substrates to patients with Alzheimer disease is worth further exploration, and future studies must be designed and powered to test a differential APOE
COMMENT Taguchi and colleagues’ recent studies suggest that reducing insulin signaling through deletion of insulin receptor substrate 2 in brain (bIRS2) increases longevity even though it induces increased peripheral insulin resistance and hyperinsulinemia. Neuro
COMMENT The elegant series of experiments by Yang et al. provide compelling evidence that increased serum retinol binding protein 4 is an important contributor to the pathogenesis of insulin resistance that is associated with a variety of genetic and environmenta
