PAPER Girodon L, Hauet P
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PAPER Limone A, Di Napoli C, Napolitano F, Imbò B, Minopoli G, Bagnoli S, Izzo A, Paladino S, Nacmias B, De Matteis MA, Montuori N, Lavecchia A, Sarnataro D
Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer's disease.
Biochim Biophys Acta Mol Basis Dis. 2025 Mar 2;1871(5):167753. Epub 2025 Mar 2 PubMed.PAPER Klein BY, Ben-David I, Gofrit ON, Greenblatt CL
Repurposing peripheral immunocytes of Bacillus Calmette Guerin-vaccinated melanoma patients to reveal preventive Alzheimer's disease mechanisms, possibly via the unfolded protein response.
J Alzheimers Dis Rep. 2025;9:25424823241309664. Epub 2025 Feb 10 PubMed.PAPER Lee YJ, Gonzales E, Wu Y, Braun KL, Martin P, Willcox B, Andel R
The association between activities and cognitive health: Stratified analysis by APOE ε4 status.
J Alzheimers Dis Rep. 2024;8(1):1502-1515. Epub 2024 Nov 24 PubMed.PAPER Matthews DG, Khorani M, Bobe G, Caruso M, Magana AA, Gray NE, Quinn JF, Stevens JF, Maier CS, Soumyanath A
Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice.
J Alzheimers Dis Rep. 2024;8(1):1611-1638. Epub 2024 Dec 4 PubMed.PAPER Wise J
Lecanemab: European drug agency upholds decision to recommend Alzheimer's drug.
BMJ. 2025 Mar 3;388:r439. PubMed.PAPER Du X, Wang H, Liu S, Song Y, Chen X, Chen Z, Zhou R, Du J, Zhang W, Gao R, Li H, Zhang G, Mao X, Chang L, Wu Y
Astrocytic GluN2A alleviates sleep deprivation-induced elevation of Aβ through regulating neprilysin and AQP4 via the calcineurin/NFAT pathway.
Prog Neurobiol. 2025 Mar 1;:102744. Epub 2025 Mar 1 PubMed.PAPER Nieves J, Gil G, Gonzalez A
A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors.
Heliyon. 2025 Feb 28;11(4):e42445. Epub 2025 Feb 4 PubMed.PSEN1 I162S
MUTATIONS PSEN1 73653565 GRCh37/hg19 rs1898533739 T G 73186857 GRCh38/hg38 T G Exon 6 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 26.0). Unknown. I162S Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed info
PSEN1 F118V
MUTATIONS PSEN1 73640287 GRCh37/hg19 T G 73173579 GRCh38/hg38 T G Exon 5 Coding Increased the Aβ42/Aβ40 ratio due to reduced Aβ40 production in cells. Unknown. F118V Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed information on carrier(s)
PSEN1 F105S
MUTATIONS PSEN1 73171023 GRCh37/hg19 T C 73637731 GRCh38/hg38 T C Exon 4 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 27.1). Unknown. F105S Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant was identifie
PAPER Gordon I, Genis I, Grauer E, Sehayek E, Michaelson DM
Biochemical and cognitive studies of apolipoprotein-E-deficient mice.
Mol Chem Neuropathol. 1996;28(1-3):97-103. PubMed.PAPER Gordon I, Grauer E, Genis I, Sehayek E, Michaelson DM
Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.
Neurosci Lett. 1995 Oct 13;199(1):1-4. PubMed.PAPER Ueno H, Takahashi Y, Mori S, Kitano E, Murakami S, Wani K, Miyazaki T, Matsumoto Y, Okamoto M, Ishihara T
Age-related behavioural abnormalities in C57BL/6.KOR-Apoe shl mice.
Transl Neurosci. 2025 Jan 1;16(1):20220363. Epub 2025 Feb 25 PubMed.PSEN1 V97M
MUTATIONS PSEN1 73637706 GRCh37/hg19 rs63750852 G A 73170998 GRCh38/hg38 G A Exon 4 Coding Unknown. V97M Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant was identified in France in individual(s) who developed Alzheimer’s disease (AD) (
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