PAPER Liu Y, Liu X, Che P, Wang Y, Piao Z, Wang Y, Cai L, Xing M, Xu Y, Sun W, Wang Y, Zhang N

A cytometric bead array for the measurement of plasma biomarker levels in patients with Alzheimer's disease.

Sci Rep. 2025 Mar 21;15(1):9767. PubMed.

PAPER Awayn NH, Hashish SA, Salem SA, Abod S, Elgahmasi SM, Ouararhni K, Abdesselem H, Abdi IY, El-Agnaf OA

Investigating the prevalence of the G2019S mutation in Parkinson's disease among a Libyan population.

J Parkinsons Dis. 2025 Mar 17;:1877718X251324407. Epub 2025 Mar 17 PubMed.

PAPER Ostrozovicova M, Tamas G, Atputhavadivel A, Dusek P, Grofik M, Han V, Holly P, Jech R, Kalinova K, Klivenyi P, Kovacs N, Kulcsarova K, Kurca E, Lackova A, Lee H, Lewis P, Magocova V, Marekova M, Murphy D, Nagano A, Necpal J, Pinter D, Rabajdova M, Ruzicka E, Serranova T, Smilowska K, Soos K, Straka I, Svorenova T, Valkovic P, Zarubova K, Gdovinova Z, Houlden H, Rizig M, Skorvanek M, CEGEMOD consortium

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early-Onset and Familial Parkinson's Disease.

Mov Disord Clin Pract. 2025 Mar 22; Epub 2025 Mar 22 PubMed.

PAPER Augustin E, Vinasco-Sandoval T, Riquelme-Perez M, Plassard D, Gaudin M, Aurégan G, Mitja J, Bernier S, Joséphine C, Petit F, Jan C, Hérard AS, Gaillard MC, Launay A, Faivre E, Buée L, Boutillier AL, Blum D, Bemelmans AP, Bonvento G, Cambon K

Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy.

Glia. 2025 Mar 22; Epub 2025 Mar 22 PubMed.

PAPER Wang L, Li B, Tang Z, Wang Y, Peng Y, Sun T, Zhang A, Qi X

Gastrodin Alleviates Tau Pathology by Targeting the Alzheimer's Risk Gene FERMT2, Reversing the Reduction in Brain Viscoelasticity.

CNS Neurosci Ther. 2025 Mar;31(3):e70283. PubMed.

PAPER Cheng M, Lu D, Li K, Wang Y, Tong X, Qi X, Yan C, Ji K, Wang J, Wang W, Lv H, Zhang X, Kong W, Zhang J, Ma J, Li K, Wang Y, Feng J, Wei P, Li Q, Shen C, Fu XD, Ma Y, Zhang X

Author Correction: Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis.

Nat Neurosci. 2025 Mar 21; Epub 2025 Mar 21 PubMed. Corrected paper.

PAPER Huang X, Steinmetz J, Marsh EK, Aravkin AY, Ashbaugh C, Murray CJ, Yang F, Ji JS, Zheng P, Sorensen RJ, Wozniak S, Hay SI, McLaughlin SA, Garcia V, Brauer M, Burkart K

A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia.

Nat Aging. 2025 Mar 21; Epub 2025 Mar 21 PubMed.

PAPER Wang M, Li M, Jiang Y, Wang S, Yang X, Naseem A, Algradi AM, Hao Z, Guan W, Chen Q, Zhang L, Kuang H, Yang B, Liu Y

Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway.

J Agric Food Chem. 2025 Apr 2;73(13):7725-7740. Epub 2025 Mar 22 PubMed.

Jason Karlawish on The Bad Medicine of Doctored

COMMENT Public Trust: Easily Cracked, Hard to Repair Seeing this page prompts me to add here an updated version of my comments posted on MedPage earlier this month. Systematic fraud, led by a "cabal of self-interested researchers, government accomplices, and

Sylvain Lehmann on ALS or Alzheimer’s? Blood Phospho-Tau Could Mean Either

COMMENT Interesting result. p-tau181 is in fact modified in ALS but from a clinical point of view, the measurement of p-tau181 is not very informative when compared to NfL. See our latest article in Neurology (Mondesert et al., 2025), which provides Class II evid

PAPER Mondesert E, Delaby C, De La Cruz E, Kuhle J, Benkert P, Pradeilles N, Duchiron M, Morchikh M, Camu W, Cristol JP, Hirtz C, Esselin F, Lehmann S

Comparative Performances of 4 Serum NfL Assays, pTau181, and GFAP in Patients With Amyotrophic Lateral Sclerosis.

Neurology. 2025 Mar 25;104(6):e213400. Epub 2025 Feb 26 PubMed.

PAPER Wang Z, Li Z, Lin A, Zhang Q, Chen Y, Bie B, Feng J

Exploration of small molecules as inhibitors of potential BACE1 protein to treat amyloid cerebrovascular disease by employing molecular modeling and simulation approaches.

PLoS One. 2025;20(3):e0317716. Epub 2025 Mar 21 PubMed.

PAPER Li N, Cui N, Bakry IA, Ma Y, Cheng Y, Zhao G, Yang H, Song L, Qiao M, Hai D, Galaverna G, Huang X

Pea Peptide Modulates Abnormal Aβ Production in PC12 Cells Induced by Lead Exposure.

Plant Foods Hum Nutr. 2025 Mar 21;80(2):98. PubMed.

PAPER Chahine LM, Lafontant DE, Choi SH, Iwaki H, Blauwendraat C, Singleton AB, Brumm MC, Alcalay RN, Merchant K, Nudelman KN, Dagher A, Vo A, Tao Q, Venuto CS, Kieburtz K, Poston KL, Bressman S, Gonzalez-Latapi P, Avants B, Coffey C, Jennings D, Tolosa E, Siderowf A, Marek K, Simuni T, Parkinson’s Progression Markers Initiative

LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization.

Brain Commun. 2025;7(2):fcaf103. Epub 2025 Mar 6 PubMed.

PAPER Koss DJ, Todd O, Menon H, Anderson Z, Yang T, Findlay L, Graham B, Palmowski P, Porter A, Morrice N, Walker L, Attems J, Ghanem SS, El-Agnaf O, LeBeau FE, Erskine D, Outeiro TF

A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.

Mol Neurodegener. 2025 Mar 20;20(1):34. PubMed.