1791 RESULTS
COMMENT Mitochondria produce energy for our cells but are also prone to damage. How does the cell know when a mitochondrion is damaged? One way is through the PINK1-Parkin mitophagy pathway, with PINK1 serving as the damage sensor (reviewed in Narendra and Youle,
PAPER Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V
COMMENT More than a decade ago, Youle, Lazarou, and Matsuda first showed biochemically that human PINK1 is stabilized on the mitochondrial TOM complex. Since then, there has been great interest in understanding the mechanism. This new cryo-EM structure represents
RESEARCH NEWS 2025-03-14 Research News A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David Komander have captured the first cryo-EM sna
PAPER Callegari S, Kirk NS, Gan ZY, Dite T, Cobbold SA, Leis A, Dagley LF, Glukhova A, Komander D
, Spain
PAPER Tagliaferro G, Davighi MG, Clemente F, Turchi F, Schiavina M, Matassini C, Goti A, Morrone A, Pierattelli R, Cardona F, Felli IC
PAPER Han MN, Di Natale MR, Lei E, Furness JB, Finkelstein DI, Hao MM, Diwakarla S, McQuade RM
PAPER Imhoff D, Sturzenegger R, Went P, Pantazis G
PAPER Forrest SL, Sadia N, Khodadadi M, Tator C, Green R, Tartaglia MC, Kovacs GG
PAPER Nakase T, Tatewaki Y, Takano Y, Nomura S, Baek HW, Taki Y
PAPER Grimaldi L, Cavallaro RA, De Angelis D, Fuso A, Sancesario G
PAPER Nakaya M, Kamagata K, Takabayashi K, Andica C, Uchida W, Hagiwara A, Akashi T, Wada A, Taoka T, Naganawa S, Abe O, Aoki S
PAPER Kakino Y, Hattori Y, Ogata S, Nakaoku Y, Nishimura K, Iida H, Ihara M
PAPER Pang S, Li Z, Liu A, Luo ZH, Yin H, Fan S, Shi J, Liu N, Pan S, Yang YJ, Zhang GJ, Chen J
