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Enhanced social interaction protects cognition by preserving synapse numbers.

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Leon French on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT I commend Grandke et al. for highlighting that their strongest pathway-level signal, "SRP-dependent cotranslational protein targeting to membrane," aligns with the gingipain hypothesis. This pathway primarily comprises ribosomal proteins, e.g. R

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bioRxiv2024.09.05.611566 .

PSEN1 Q223K

MUTATIONS PSEN1 73659470 GRCh37/hg19 rs1898776259 C A 73192762 GRCh38/hg38 rs1898776259 C A Exon 7 Coding Increased Aβ42 levels and the Aβ42/Aβ40 ratio in cells. Unknown. Q223K Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed information on

PSEN1 W165L

MUTATIONS PSEN1 73653574 GRCh37/hg19 rs1898534725 G T 73186866 GRCh38/hg38 G T Exon 6 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 28.3). Unknown. W165L Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed info

Yizhou A. Liu

Washington University in St Louis School of Medicine
United States

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