Meghan Cash

, Canada

Ziyuan Huang

UMass Chan
United States

James Rowland on BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer's disease.

COMMENT Neuronal hyperactivity has long been known as a hallmark of Aβ pathology in Alzheimer’s disease (AD), with hyperactive neurons clustered around plaques (Busche et al., 2008). This Aβ-induced hyperactivity has been posited as a driver of tau propagation th

Nishi Arora

Germany

Kristine Shields on Two New Deaths on Leqembi Highlight Need to Better Manage ARIA

COMMENT Given that "males taking lecanemab showed a 43 percent mean slowing of cognitive decline, which is statistically significant. Females, meanwhile, had a non-significant 12 percent mean slowing on the drug" (Andrews et al., 2025), are clinicians u

PAPER Samuelsson J, Glans I, Stubbendorff A, Ericson U, Palmqvist S, Hansson O, Sonestedt E

Associations between the EAT-Lancet planetary health diet and incident dementia.

J Prev Alzheimers Dis. 2025 Apr 12;:100166. Epub 2025 Apr 12 PubMed.

PAPER Azarfarin M, Moradikor N, Salatin S, Sarailoo M, Dadkhah M

Stress-related neurodegenerative diseases: Molecular mechanisms implicated in neurodegeneration and therapeutic strategies.

Prog Brain Res. 2025;291:253-288. Epub 2025 Feb 6 PubMed.

PAPER Turton SM, Padgett S, Maisel MT, Johnson CE, Buzinova VA, Barth SE, Kohler K, Spearman HM, Macheda T, Manauis EC, Guo LZ, Whitlock HR, Bachstetter AD, Sunderam S, O'Hara BF, Duncan MJ, Murphy MP

Interactions between daily sleep-wake rhythms, γ-secretase, and amyloid-β peptide pathology point to complex underlying relationships.

Biochim Biophys Acta Mol Basis Dis. 2025 Apr 11;:167840. Epub 2025 Apr 11 PubMed.

PAPER Gu J, Chen Y, Tang H, Chen X, Xing S

Impaired glymphatic system is associated with secondary neuronal injury in the thalamus following cerebral cortical infarction.

Brain Res Bull. 2025 May;224:111330. Epub 2025 Apr 1 PubMed.

PAPER Wei R, Buss SS, Milde R, Fernandes M, Sumsion D, Davis E, Kong WY, Xiong Y, Veltink J, Rao S, Westover TM, Petersen L, Turley N, Singh A, Das S, Junior VM, Ghanta M, Gupta A, Kim J, Lam AD, Stone KL, Mignot E, Hwang D, Trotti LM, Clifford GD, Katwa U, Thomas RJ, Mukerji S, Zafar SF, Westover MB, Sun H

Automated phenotyping of mild cognitive impairment and Alzheimer's disease and related dementias using electronic health records.

Int J Med Inform. 2025 Apr 11;200:105917. Epub 2025 Apr 11 PubMed.

PAPER Oraby S, Emran A, El-Saghir B, Mohsen S

Hybrid of DSR-GAN and CNN for Alzheimer disease detection based on MRI images.

Sci Rep. 2025 Apr 13;15(1):12727. PubMed.

PAPER Salgado KD, Nascimento RG, Albuquerque AL, Oliveira LA, Pinto Coelho Nogueira KO

Melatonin protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25-35.

Brain Res. 2025 Apr 11;:149637. Epub 2025 Apr 11 PubMed.

PAPER Felbecker A, Rouaud O, Lathuilliere A, Allali G, Sollberger M, Meyer-Heim T, Monsch AU, Lövblad KO, Becker S, Barro-Belaygues N, Popp J, Bürge M, Lindheimer K, Gietl A, Jung HH, Georgescu D, Meyer R, Frisoni GB

Anti-amyloid monoclonal antibodies for the treatment of Alzheimer disease: Intersocietal recommendations for their appropriate use in Switzerland.

Neurodegener Dis. 2025 Apr 11; Epub 2025 Apr 11 PubMed.

PAPER Oliveri F, Bicaj M, Cillerai M, Cabona C, Gemelli C, Uccelli A, Schenone A, Ferraro PM

Prevalence of cognitive impairment in motor neuron diseases: alternative norming methods lead to considerably diverse estimates.

Amyotroph Lateral Scler Frontotemporal Degener. 2025 Apr 13;:1-6. Epub 2025 Apr 13 PubMed.

PAPER Wu M, Chen YF, Yao W, Zhou S, Xie Z, Tao Y, Zhong Y, Ma W

The anti-inflammatory drug Montelukast ameliorates cognitive deficits by rescuing the inflammatory levels in young AD animal models.

Sci Rep. 2025 Apr 13;15(1):12720. PubMed.