PAPER Li W, Zhou J, Li S, Wu M, Zhu Y, Chen Q, Chen F, Ma X, Zhang X, Wang Z, Lu J, Zhang B
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PAPER Jiang Y, Jin Z, Wang H, He X, Fu R, Yu X, Fu Q, Tian J, Li W, Zhu X, Zhang S, Lu Y
A dose-response meta-analysis of physical activity and the risk of alzheimer's disease in prospective studies.
J Neurol. 2025 Mar 7;272(4):256. PubMed.PAPER Jiang R, Zheng X, Sun J, Chen L, Xu G, Zhang R
Classification for Alzheimer's disease and frontotemporal dementia via resting-state electroencephalography-based coherence and convolutional neural network.
Cogn Neurodyn. 2025 Dec;19(1):46. Epub 2025 Mar 4 PubMed.PAPER Carroll E, Scaber J, Huber KV, Brennan PE, Thompson AG, Turner MR, Talbot K
Drug repurposing in amyotrophic lateral sclerosis (ALS).
Expert Opin Drug Discov. 2025 Mar 7;:1-18. Epub 2025 Mar 7 PubMed.PAPER Galeano Niño JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E, Taylor A, Minot SS, Johnston CD, Bullman S
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.
Nature. 2022 Nov;611(7937):810-817. Epub 2022 Nov 16 PubMed.PAPER Tan CC, Ko KK, Chen H, Liu J, Loh M, SG10K_Health Consortium, Chia M, Nagarajan N
No evidence for a common blood microbiome based on a population study of 9,770 healthy humans.
Nat Microbiol. 2023 May;8(5):973-985. Epub 2023 Mar 30 PubMed.Rupal Mehta on Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?
COMMENT It is remarkable how much remains unknown about the normal structure of blood vessels in the mammalian brain, and about how cerebral vessel structure changes with age. The anatomy has been understudied, and routine staining methods and transmission electr
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
RESEARCH NEWS 2025-03-07 Research News Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a study published February 18 in Proceedings o
Neural Stem Cells: Capturing Complexity and Plasticity from the Cell to the Organism
CONFERENCE 2025-04-03 00:00:00-2025-04-04 00:00:00 Athens, Greece 03 – 04 April 2025 View Conference Website 0
Brain Organoids Summer Symposium
CONFERENCE 2025-06-11 00:00:00-2025-06-13 00:00:00 Bilbao, Spain 11 – 13 June 2025 View Conference Website 0
Rashi Mehta on Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?
COMMENT It is interesting that the brain vasculature was found to be exceptionally sensitive to mucin-type-O-glycan perturbations. Time dependency of the effects of the mucin protease StcE on the endothelial glycoprotein layer and barrier function is also relevan
APP L723R
MUTATIONS APP 27264077 GRCh37/hg19 T G 25891765 GRCh38/hg38 T G Exon 17 Coding Increased Aβ42 and decreased Aβ40 levels resulting in an increased Aβ42/Aβ40 ratio in cells. Unknown. L723R Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant
Malu G. Tansey, Rebecca Wallings on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
COMMENT A wealth of literature demonstrates that the arsenal of inflammatory responses in males is radically different from that in females. If one acknowledges that females experience giving birth, and that pain tolerance is regulated by inflammatory signaling l
Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
RESEARCH NEWS 2025-03-07 Research News Despite growing recognition of the importance of the peripheral immune system in neurodegenerative disease, little is known about how these blood cells change in Alzheimer’s and Parkinson’s diseases. In the February 25 Nature Communications,
Enrico Glaab on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
COMMENT This study makes a significant contribution to our understanding of sex-specific immune signatures in neurodegenerative diseases. The authors have created a comprehensive single-cell atlas of peripheral blood mononuclear cells from patients with Alzheimer
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