PAPER Bahrami F, Morris DL, Rufener L, Pourgholami MH

Anticancer properties of novel aminoacetonitrile derivative monepantel (ADD 1566) in pre-clinical models of human ovarian cancer.

Am J Cancer Res. 2014;4(5):545-57. Epub 2014 Sep 6 PubMed.

New Partnership Forms to Harness AI for Alzheimer’s Research

CONFERENCE COVERAGE 2025-04-11 Conference Coverage As advanced biomedical technologies have allowed scientists to gather growing and increasingly complex datasets, even the most brilliant human minds grappling with the windfall can’t possibly keep up. Yawning gaps have spread out betwe

Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s

CONFERENCE COVERAGE 2025-04-11 Conference Coverage Austria’s beautiful capital city of Vienna hosted the 19th International Conference on Alzheimer’s and Parkinson’s diseases, which drew a record 5,554 attendees from 76 countries. From April 1 to 5, scientists shared their latest findi

PrimeC

THERAPEUTICS NeuroSense Therapeutics Ciprofloxacin and Celecoxib Combination Inflammation Metals Other From November 2019 to January 2021, a one-year, open-label pilot trial in Israel enrolled 16 ALS patients. Participants took 909 mg celecoxib and ciprofloxacin daily

PAPER Nagel MA, Bubak AN

Varicella Zoster Virus Vasculopathy.

J Infect Dis. 2018 Sep 22;218(suppl_2):S107-S112. PubMed.

Zapping the Zoster Virus, Dodging Dementia

RESEARCH NEWS 2025-04-11 Research News Vaccination against shingles may come with a surprising perk. A recent study posits that the vaccine for herpes zoster, also known as shingles, protects against more than a painful, angry rash. According to real-world data, individuals who r

PAPER Mabuchi F, Tang S, Ando D, Yamakita M, Wang J, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S

The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population.

Mol Vis. 2005 Aug 12;11:609-12. PubMed.

PAPER Shi Y, Liu W, Hu J, Qiu WQ, He X, Gao Y, Zhang X, Fan Z

The Role of Menopause and Its Association with the Apolipoprotein E4 Allele for Age at Diagnosis of Glaucoma in Women.

Ophthalmol Sci. 2025;5(4):100726. Epub 2025 Jan 31 PubMed.

AD/PD™ 2025: Advances in Science & Therapy

CONFERENCE COVERAGE SERIES Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s New Partnership Forms to Harness AI for Alzheimer’s Research Moving Target: New Biology Casts TREM2 as a Shifty Mark TREM2: A Chill Pill for Neurons? Trialists Grapple with How to

PAPER Andrieu S, Bateman RJ, Bereczki E, Bose N, Brookes AJ, Doraiswamy PM, Kivipelto M, Kohlhaas S, Kourtis L, Middleton LT, Moore GJ, Petrella JR, Postlethwaite N, Sainz-Fuertes R

Harnessing artificial intelligence to transform Alzheimer's disease research.

Nat Med. 2025 Apr 1; Epub 2025 Apr 1 PubMed.

NUZ-001

THERAPEUTICS N-[(2S)-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl]-4-(trifluoromethylsulfanyl)benzamide Neurizon Therapeutics S-Monepantel Zolvix® Small Molecule Other A Phase 1 pilot in six cancer patients found 28 days of 5 mg/kg daily monepantel to hav

Takaomi Saido on ALS or Alzheimer’s? Blood Phospho-Tau Could Mean Either

COMMENT Gonzalez-Ortiz devised a new method to quantify brain-derived tau (Gonzalez-Ortiz et al., 2022). If this technology can distinguish between brain- and muscle-derived tau species, it will be possible to determine whether the phospho-tau species detected in

Kristján Holt

The University of Ediburgh
United Kingdom

PAPER Nadh AG, Kunhikrishnan MJ, Ravi V, Ramakrishnan K, Rehman N, Adithya KS, Revikumar A, Sudhakaran PR, Raju R

Convolidine as potent BACE1 inhibitor for Alzheimer's disease; in-silico coupled with in-vitro assessment.

J Comput Aided Mol Des. 2025 Apr 10;39(1):13. PubMed.

PAPER Mohammadi S, Dolatshahi M, Rahmani F, Raji CA

Altered Clearance in Alzheimer's Disease and Cerebral Amyloid Angiopathy.

Neuroimaging Clin N Am. 2025 May;35(2):277-286. Epub 2025 Feb 19 PubMed.