348441 RESULTS
RESEARCH NEWS 2001-10-30 Research News Never mind that the lowly yeast has no brain. It nevertheless makes a good model for studying the cellular pathology of-and screening for drugs against-polyglutamine expansion diseases such as Huntington's, claim researchers led by Robe
RESEARCH NEWS 2001-10-30 Research News An international team lead by John Fink, University of Michigan, has identified a new gene responsible for hereditary spastic paraplegia (HSP). This disorder, which starts in early childhood and can completely paralyze both legs, has been li
RESEARCH NEWS 2001-10-29 Research News 29 October 2001. Estrogen replacement therapy may protect postmenopausal women from Alzheimer's disease, according to some epidemiological studies. For example, a recent short trial of high-dose 17β-estradiol found significant improveme
RESEARCH NEWS 2001-10-26 Research News Scientists at the Icelandic genomics company DeCode Genetics, working with colleagues at the National University Hospital in Reykjavik, have presented at last week's meeting of the American Society for Human Genetics in San Diego a post
RESEARCH NEWS 2001-10-25 Research News The ErbB family of cell surface receptors is involved in the transduction of cellular growth and proliferation signals; ErbB-1 and ErbB-2, for example, have been implicated in aggressive forms of breast cancer. In tomorrow's Science Exp
RESEARCH NEWS 2001-10-25 Research News Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA-mRNA, tRNA, rRNA-has just gotten a baby brother. Three independent research teams are reporting in tomorrow's Sci
RESEARCH NEWS 2001-10-19 Research News One hypothesis for how polyglutamine (poly-Q) repeats in the huntingtin protein might cause disease holds that they somehow perturb gene expression. This notion is getting more traction from a paper in yesterday's Nature, which shows no
RESEARCH NEWS 2001-10-19 Research News Another theory to explain Huntington's suggests that proteolysis of polyglutamine-expanded (poly-Q) huntingtin by caspase enzymes generates toxic N-terminal peptide fragments. Though caspases are required for apoptosis induction by muta
COMMENT Comment by Mark Gluck, Kin Ho Chan, M. Todd Allen Although these results are intriguing, the authors' interpretation of them seems to go beyond what the data actually might support. Briefly, the pattern of results they report is that as you look at a
RESEARCH NEWS 2001-10-18 Research News The Where? Key Role Found for Entorhinal Cortex, Area of Earliest Neuron Death in Alzheimer's It has become almost a truism in memory research that the seahorse-shaped brain area called the hippocampus is key to memory formation. It hel
RESEARCH NEWS 2001-10-15 Research News Chronically elevated levels of cyclooxygenase-2 (COX-2), which catalyzes the first step in the synthesis of prostaglandins from arachidonic acid, have been correlated with induction of neuronal apoptosis, suggesting this enzyme may play a ro
RESEARCH NEWS 2001-10-15 Research News Mitochondria, through their pivotal roles in apoptosis and generation of reactive oxygen species (ROS), are increasingly being implicated in the pathogenesis of neurodegenerative diseases. Researchers in the lab of Nils-Göran Larsson at the
RESEARCH NEWS 2001-10-15 Research News Last year researchers identified a mutation in rats, the so-called agu mutation (Payne et al), which resulted in a phenotype resembling human Parkinsonism. In November's Nature Neuroscience, available online today, scientists at Wayne D
RESEARCH NEWS 2001-10-10 Research News 10 October. In tomorrow's Science, researchers describe how developing a new method dubbed "pharmacological knock-in" has enabled them to fill in the missing pieces of an unusual signal transduction pathway that links changes
RESEARCH NEWS 2001-10-09 Research News Researchers have suspected retroviruses to play a role in amyotrophic lateral sclerosis (ALS) since the 1960s, when poliomyelitis was proposed to contribute to progression of the disease. Through the '80s and '90s, ALS syndromes as
