348369 RESULTS
RESEARCH NEWS 2001-05-31 Research News Obesity and its frequent cousin, insulin-resistant diabetes, so clearly increase the risk for atherosclerosis that the whole disease complex has been called metabolic syndrome. The underlying mechanisms for this unhappy connection remain poo
RESEARCH NEWS 2001-05-30 Research News Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is the most common motor neuron disease in humans, affecting one in 1,000. It results in a progressive loss of motor neuron function, leading to paralysis and death
COMMENT Reply to Dr. Scatty by Ming Chen Conceptualization of Ca2+ signals in the brain as dynamic "spikes" (1-3), instead of traditionally perceived steady-state "level" changes, is essential to explain some key dilemmas that have severely ha
RESEARCH NEWS 2001-05-25 Research News Aggregates of proteins are a common feature in many neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, fronto-temporal dementia and ALS. Their role in contributing to these diseases remains unclear.
RESEARCH NEWS 2001-05-25 Research News While much Alzheimer's research has focused on mechanisms that result in the formation of amyloid plaques, a growing body of evidence indicates that processes that break down Aβ are just as important, and may offer novel targets for the
RESEARCH NEWS 2001-05-24 Research News A study in the June issue of Nature Neuroscience points a finger at proteins of the Shc family as the critical link in signaling neural stem cells to either remain in their pluripotent form or differentiate into mature neurons. Italian resea
RESEARCH NEWS 2001-05-18 Research News The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and antigen-presenting cells. In both systems, membrane protei
RESEARCH NEWS 2001-05-18 Research News The Journal of Alzheimer's Disease has awarded the 2001 Alzheimer Medal to Luciano D'Adamio for his article, "Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid-β protein precu
RESEARCH NEWS 2001-05-17 Research News (From Nature press release.) Permanent memories are thought to be stored in the cortex, but little is known about the processes that incorporate memories into cortical networks. Now [in today's Nature] Alcino J. Silva of the University
RESEARCH NEWS 2001-05-17 Research News (From Nature press release.) The path from identifying a genome sequence to pinpointing the contribution of each gene is beset with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies between what
COMMENT I have to admit that the emphasis in calcium signaling can be a useful way to solve the old controversy over the role of calcium in AD. Apparently, experimentalists have been assuming that the time scale of calcium signaling is the same as that of the ins
RESEARCH NEWS 2001-05-08 Research News Stem cells from the bone marrow of adults may be as flexible as embryonic stem cells, according a study in the current issue of Cell. Researchers at Yale, New York University, and Johns Hopkins found that these cells, which continuously repl
RESEARCH NEWS 2001-05-03 Research News Two reports in tomorrow's Science add to a growing body of evidence that glial cells play more than a "housekeeping" role and are essential for neuronal signalling (see also 26 January news). M. Iino and colleagues report that
RESEARCH NEWS 2001-05-03 Research News (From Science press release) In a prime example of what science can accomplish in the "post-genomic" era, researchers have pieced together the functions of a variety of genes involved in a yeast metabolism pathway. If an organism&#
RESEARCH NEWS 2001-05-01 Research News A closer look at mitochondria in Alzheimer's disease confirms that oxidative damage to these cellular power plants is a central feature of the disease, according to a report in the May 1 issue of the Journal of Neuroscience. The study,
