348369 RESULTS
RESEARCH NEWS 2001-07-25 Research News It has been clear for a number of years that iron accumulates in areas such as the hippocampus in Alzheimer's disease and the substantia nigra in Parkinson's disease. Just what this means is uncertain, especially in given that iron
COMMENT Reply to Dr. Wong by Ming Chen First, let me take this opportunity to thank Drs. Wong, Scatty and Aldoso for raising in-depth and sharp questions. In science, asking the right questions sometimes can be as important as solving them. The AD field today nee
RESEARCH NEWS 2001-07-18 Research News Thirty European Alzheimer's Disease Centers of excellence and one nongovernmental organization, Alzheimer Europe, have established a network to carry out multicentre interventional trials under the auspices of the European Commission. T
RESEARCH NEWS 2001-07-12 Research News It has become part of the standard lore on Alzheimer's that a series of enzymes-dubbed α-, β-, and γ-secretase-successively chops away at the APP cell-surface protein, and that one product of γ-secretase is the infamous Aβ-peptide. Yet
RESEARCH NEWS 2001-07-07 Research News Using different approaches, two recent animal studies have reported some success toward achieving a goal common to several experimental AD therapies: both methods significantly lowered the Aβ burden in the brain. In last month's Neuron,
RESEARCH NEWS 2001-07-01 Research News Most research trying to coax adult central nervous system neurons into repairing nerve injury focuses on the environment through which regenerating neurons have to extend new growth cones and axons. A study published today in the Journal of
COMMENT A very stimulating hypothesis. But, a problem is that it is all based on your findings in a single experimental paper suggesting that alpha-secretase may be a calpain. At the same time, however, there are over 50 or so proteases being also proposed today
RESEARCH NEWS 2001-06-28 Research News 28 June, 2001. Researchers at Japan's Juntendo University School of Medicine report in tomorrow's Cell that they have identified a novel substrate for the parkin E3 ligase function (see previous story below.) Yuzuru Imai, Ryosuke T
RESEARCH NEWS 2001-06-28 Research News The two most prominent genes linked to inherited, monogenic Parkinson's disease-α-synuclein and parkin-are generally thought to be unconnected to each other because the forms of PD they cause are clinically and neuropathologically diffe
RESEARCH NEWS 2001-06-21 Research News The γ-secretase enzyme activity is a therapeutic target in Alzheimer's disease. Yet its promise of lowering the Aβ42 burden has been under a cloud since 1999, when Bart De Strooper and other scientists found that the enzyme also cleaves
COMMENT Reply to Dr. Aldoso by Ming Chen In the world of research, we develop hypotheses based on facts. But perhaps the most difficult job is to judge, among the numerous reports, which ones are facts and which are not. Many papers have reported that calcium ant
RESEARCH NEWS 2001-06-15 Research News The gene mutation that causes Huntington's disease has been known for many years, yet the function of the encoded protein, huntingtin, and the pathogenic mechanism of the mutant protein, have remained frustratingly elusive. Various stud
RESEARCH NEWS 2001-06-14 Research News Harvard researchers have expressed the wildtype and mutant forms of human tau protein in Drosophila, creating a new model for one aspect of Alzheimer’s disease pathology as well as for tauopathies. In tomorrow’s Science, Mel Feany and collab
RESEARCH NEWS 2001-06-14 Research News Abnormal forms of the prion protein are thought to be the infective agent responsible for bovine spongiform encephalopathy (BSE, or "mad cow disease") and its human form, variant Creutzfeldt-Jakob disease (vCJD). The pathogenic pri
COMMENT To my knowledge, there are probably over a hundred of reports showing that calcium channel blockers have protective effects in old cells or animals and even in AD patients. So, whatever your theory is (though it is interesting), a rule is that one cannot
