PAPER Callegari S, Kirk NS, Gan ZY, Dite T, Cobbold SA, Leis A, Dagley LF, Glukhova A, Komander D

Structure of human PINK1 at a mitochondrial TOM-VDAC array

Science, 13 March 2025 .

Aurore Delvenne on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT The mechanisms underlying the disruption of the choroid plexus in aging and age-related neurodegenerative diseases remain relatively underexplored. In this insightful study, Chen et al. provide compelling evidence that macrophage activity plays a crucial

Tord Labuda

Alzinova AB
, Sweden

Stefan Pierrou

Alzinova AB
, Sweden

PAPER Alldred MJ, Ibrahim KW, Pidikiti H, Lee SH, Heguy A, Chiosis G, Mufson EJ, Stutzmann GE, Ginsberg SD

Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

Front Mol Neurosci. 2025;18:1546375. Epub 2025 Feb 26 PubMed.

PAPER Sohur US, Gray DL, Duvvuri S, Zhang Y, Thayer K, Feng G

Phase 1 Parkinson's Disease Studies Show the Dopamine D1/D5 Agonist PF-06649751 is Safe and Well Tolerated.

Neurol Ther. 2018 Dec;7(2):307-319. Epub 2018 Oct 25 PubMed.

PAPER Gray DL, Allen JA, Mente S, O'Connor RE, DeMarco GJ, Efremov I, Tierney P, Volfson D, Davoren J, Guilmette E, Salafia M, Kozak R, Ehlers MD

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

Nat Commun. 2018 Feb 14;9(1):674. PubMed.

Richard Ransohoff on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT This paper focuses useful attention on the choroid plexus as a potential contributor to brain aging. The approach taken was to evaluate tight junctions of the CP epithelium, identifying claudin-1 (product of the CLDN1 gene) as declining in abundance with

PAPER Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

Sci Transl Med. 2023 Jan 18;15(679):eabq6288. Epub 2023 Jan 18 PubMed.

Fanny Ehret

, Germany

PAPER Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J

Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease.

NPJ Parkinsons Dis. 2025 Mar 11;11(1):46. PubMed.

PAPER Vaidya B, Biswas S, Roy I, Sharma SS

HC070, a Transient Receptor Potential Canonical 5 (TRPC5) Channels Inhibitor Ameliorated α-synuclein Preformed Fibrils-Induced Parkinson's Disease: A Neurobehavioural and Mechanistic Study.

J Biochem Mol Toxicol. 2025 Mar;39(3):e70207. PubMed.

PAPER Dubljević O, Pavković Ž, Srbovan M, Potrebić M, Stanojlović M, Pešić V

Attention-deficit/hyperactivity disorder-related psychomotor activity and altered neuronal activity in the medial prefrontal cortex and striatum in the A53T mouse model of Parkinson's disease and other synucleinopathies: Findings from an "endophenotype" a

Prog Neuropsychopharmacol Biol Psychiatry. 2025 Mar 20;137:111273. Epub 2025 Jan 25 PubMed.

PAPER Cappa SF

Hemispheric asymmetry in neurodegenerative diseases.

Handb Clin Neurol. 2025;208:101-112. PubMed.

PAPER Hadzibegovic S, Nicole O, Andelkovic V, de Gannes FP, Hurtier A, Lagroye I, Bontempi B

Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged mice.

Sci Rep. 2025 Mar 11;15(1):8365. PubMed.