Michael Guo on Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.

COMMENT The authors leverage cutting-edge tools to large sequencing datasets in order to examine Variable Number Tandem Repeats, which, given their repetitive nature, have been traditionally very challenging to study at scale. The authors find multiple VNTRs that

PAPER Heath A, McNerney MW, Yesavage J

Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.

Neurol Genet. 2025 Apr;11(2):e200241. Epub 2025 Feb 14 PubMed.

Donald Weaver on Can Autoimmunity Spark Alzheimer’s Disease?

COMMENT This paper contributes significantly to our understanding of the role of dysregulated adaptive immunity in the pathogenesis of Alzheimer’s disease. It represents a significant body of knowledge regarding how autoimmunity may contribute to AD risk. The aut

Rebecca Wallings

Indiana University
United States

Elaine Lim on Can Autoimmunity Spark Alzheimer’s Disease?

COMMENT I believe this is among the first, if not the first, large-scale, systematic study of electronic medical records (EHR) testing associations between Alzheimer’s and 26 autoimmune diseases. I found the paper super interesting because several studies have re

Chun Keung Shum

PAPER Buchholz E, Machule ML, Buthut M, Stefanovski L, Rössling R, Prüss H

Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease.

J Neurol. 2025 Mar 5;272(3):247. PubMed.

PAPER Abdeen AH, Trist BG, Nikseresht S, Harwood R, Roudeau S, Rowlands BD, Kreilaus F, Cottam V, Mor D, Richardson M, Siciliano J, Forkgen J, Schaffer G, Genoud S, Li AA, Proschogo N, Antonio B, Falkenberg G, Brueckner D, Kysenius K, Liddell JR, Fat SC, Wu S, Fifita J, Lockwood TE, Bishop DP, Blair I, Ortega R, Crouch PJ, Double KL

Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model.

Acta Neuropathol. 2025 Mar 5;149(1):22. PubMed.

PAPER Reho P, Kalia V, Jackson GL, Wang F, Eiten E, Brennan K, Brickman AM, Mayeux R, Miller GW, Vardarajan BN, Baccarelli A, Wu H

Preclinical Alzheimer's disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort.

Alzheimers Dement. 2025 Mar;21(3):e70050. PubMed.

PAPER Sirerol-Piquer MS, Perez-Villalba A, Duart-Abadia P, Belenguer G, Gómez-Pinedo U, Blasco-Chamarro L, Carrillo-Barberà P, Pérez-Cañamás A, Navarro-Garrido V, Dehay B, Vila M, Vitorica J, Pérez-Sánchez F, Fariñas I

Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species.

Mol Neurodegener. 2025 Mar 5;20(1):26. PubMed.

PAPER Xu J, Su Y, Sha Y, Fu J, Yan T, Xu F, Tang H, Ying Y, Xia Y, Dong Q, Gurol ME, Ni J, Cheng X

Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification.

Alzheimers Dement. 2025 Mar;21(3):e70044. PubMed.

PAPER Ma L, Wang Y, Huynh AL, Amadoru S, Wrigley S, Yates P, Masters CL, Goudey B, Jin L, Pan Y

Exploring epidemiological risk factors for cerebral amyloid angiopathy: Considerations for monoclonal antibody therapy in people with Alzheimer's disease.

Alzheimers Dement. 2025 Mar;21(3):e14602. PubMed.

PAPER Chu C, Wang Y, Ma L, Mutimer CA, Ji G, Shi H, Yassi N, Masters CL, Goudey B, Jin L, Pan Y

Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity.

Alzheimers Dement. 2025 Mar;21(3):e14583. PubMed.

PAPER Achouri-Rassas A, Fray S, Said Z, Ben Sassi S, Ben Ali N, Baraket G

Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.

Neurol Res. 2025 Mar 5;:1-6. Epub 2025 Mar 5 PubMed.

PAPER Kim SA, Shin D, Ham H, Kim Y, Gu Y, Kim HJ, Na DL, Zetterberg H, Blennow K, Seo SW, Jang H, Precision Medicine Platform for Mild Cognitive Impairment Based on Multi-omics, Imaging, Evidence-Based R&BD (PREMIER) Consortium

Physical Activity, Alzheimer Plasma Biomarkers, and Cognition.

JAMA Netw Open. 2025 Mar 3;8(3):e250096. PubMed.