PAPER Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE
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PAPER Hu J, Luo Y, Wang X
Multi-omics analysis of druggable genes to facilitate Alzheimer's disease therapy: A multi-cohort machine learning study.
J Prev Alzheimers Dis. 2025 Mar 11;:100128. Epub 2025 Mar 11 PubMed.PAPER Hsu KC, Huang SM, Shen JY, Chan LY, Lai PY, Lin CY
Explore peptides extracted from gliadin hydrolysates suppressing BACE1 activity and restraining Aβ protein deposition.
Int J Biol Macromol. 2025 Mar 10;:141932. Epub 2025 Mar 10 PubMed.PAPER Rahman MW, Sharma P, Chattopadhyay T, Saroja SR
Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies.
J Biol Chem. 2025 Mar 10;:108396. Epub 2025 Mar 10 PubMed.PAPER Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J
Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease.
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HC070, a Transient Receptor Potential Canonical 5 (TRPC5) Channels Inhibitor Ameliorated α-synuclein Preformed Fibrils-Induced Parkinson's Disease: A Neurobehavioural and Mechanistic Study.
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Attention-deficit/hyperactivity disorder-related psychomotor activity and altered neuronal activity in the medial prefrontal cortex and striatum in the A53T mouse model of Parkinson's disease and other synucleinopathies: Findings from an "endophenotype" a
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Mar 20;137:111273. Epub 2025 Jan 25 PubMed.PAPER Cappa SF
Hemispheric asymmetry in neurodegenerative diseases.
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Korea Brain Research Institute
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Kaitlin Casaletto on Confirmed: Women Accumulate Tangles Faster Than Do Men
COMMENT This paper is a massive accomplishment, representing the most robust evidence yet of female-specific vulnerability to tau aggregation. Applying a meta-analytic approach, the authors pooled estimates across six studies, including more than 1,300 participan
Pierre Tariot on Confirmed: Women Accumulate Tangles Faster Than Do Men
COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex
Confirmed: Women Accumulate Tangles Faster Than Do Men
RESEARCH NEWS 2025-03-12 Research News Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the strongest evidence yet. In the March 3 JAM
Nicolai Franzmeier, Davina Biel on Confirmed: Women Accumulate Tangles Faster Than Do Men
COMMENT This meta-analysis by Coughlan et al. provides robust evidence across six longitudinal cohorts, showing that women accumulate tau pathology faster than men in preclinical AD. This work is of high clinical relevance, as the transition from amyloidosis to t
PAPER Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ
Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.
JAMA Netw Open. 2025 Mar 3;8(3):e250562. PubMed.Masoud Ghamari-Langroudi
United States
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