COMMENT I commend Grandke et al. for highlighting that their strongest pathway-level signal, "SRP-dependent cotranslational protein targeting to membrane," aligns with the gingipain hypothesis. This pathway primarily comprises ribosomal proteins, e.g. R

PAPER Avey DR, Ng B, Vialle RA, Kearns NA, Lopes Kd, Iatrou A, Tissera SD, Vyas H, Saunders DM, Flood DJ, Xu J, Tasaki S, Gaiteri C, Bennett DA, Wang Y

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics

bioRxiv2024.09.05.611566 .

PSEN1 Q223K

MUTATIONS PSEN1 73659470 GRCh37/hg19 rs1898776259 C A 73192762 GRCh38/hg38 rs1898776259 C A Exon 7 Coding Increased Aβ42 levels and the Aβ42/Aβ40 ratio in cells. Unknown. Q223K Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed information on

PSEN1 W165L

MUTATIONS PSEN1 73653574 GRCh37/hg19 rs1898534725 G T 73186866 GRCh38/hg38 G T Exon 6 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 28.3). Unknown. W165L Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed info

Yizhou A. Liu

Washington University in St Louis School of Medicine
United States

PAPER Kshirsagar S, Islam MA, Reddy AP, Reddy PH

Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars.

J Alzheimers Dis Rep. 2025;9:25424823241310716. Epub 2025 Jan 15 PubMed.

PAPER Wang Q, Xu L, Shan Y, Shen W, Li L, Bi XA, Liu Z

CPST-GAN: Conditional Probabilistic State Transition Generative Adversarial Network With the Biomedical Large Foundation Models.

IEEE Trans Neural Netw Learn Syst. 2025 Feb 27;PP Epub 2025 Feb 27 PubMed.

PAPER Song F, Li Y, Jiang M, Li K, Zhang J, Zhang Y, Pang Z

HSGO: Harmonized Swarm Learning With Guided Optimization for Multi-Center sMRI Classification of Alzheimer's Disease.

IEEE J Biomed Health Inform. 2025 Jan 20;PP Epub 2025 Jan 20 PubMed.

PAPER Saikusa K, Kinumi T, Kato M

Development of amyloid β (1-42) certified reference material NMIJ CRM 6210-a.

Anal Bioanal Chem. 2025 Mar 5; Epub 2025 Mar 5 PubMed.

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