6281 RESULTS
RESEARCH NEWS 2000-07-27 Research News Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies, report scientists at Mayo Clinic Jacksonville in the August issue of Na
INTERVIEWS 2000-07-26 Interviews ARF: Dr. Mayeux, your research has revealed several risk factors that are associated with AD. What do you think are the most important risk factors for the development of AD? RM: I think the most significant risk factors are genetic. The eviden
CONFERENCE COVERAGE 2000-07-26 Conference Coverage Reported by Paul Coleman Bradley T. Hyman and Paul D. Coleman, Chairs This symposium (held 10 July) covered the gamut of age-related evolution of brain function in AD from behavioral studies emphasizing mild cognitive impairment (MCI)
CONFERENCE COVERAGE 2000-07-26 Conference Coverage The relative paucity of presentations utilizing array technologies to study alterations of gene expression in Alzheimer's disease indicates that these powerful technologies are yet to be fully utilized in the study of AD. Three la
CONFERENCE COVERAGE 2000-07-26 Conference Coverage Mild cognitive impairment (MCI) has been defined as a clinical entity whose characteristics were reviewed by Ron Petersen. Persons with MCI have memory impairment beyond what would be expected for age, yet they are not demented. These
CONFERENCE COVERAGE 2000-07-17 Conference Coverage There were a number of oral and poster presentations relating to BACE biology (abstracts 313, 504, 540, 1013, 1269 and 1272). As with the original descriptions of BACE, the reports presented at this meeting were in broad agreement. Und
CONFERENCE COVERAGE 2000-07-17 Conference Coverage The scientific highlight of the Prof. Henry Wisniewski memorial symposium (12 July) was an informative lecture about familial British dementia (FBD) delivered by Blas Frangione. His studies with the 34 amino acid long ABri protein (abs
CONFERENCE COVERAGE 2000-07-17 Conference Coverage Almost 12% (152) of the 1,307 abstracts presented at the 7th International Conference on Alzheimer’s Disease and related disorders made reference to presenilin (PS). For an overview of PS biology check out the webcast of Bruce Yankner’
CONFERENCE COVERAGE 2000-07-17 Conference Coverage One of the great unsolved mysteries of Alzheimer's disease is the link between the disease's two major lesions: Aβ amyloid plaques and tau tangles. Proponents of the amyloid cascade hypothesis presume that the former causes t
CONFERENCE COVERAGE 2000-07-14 Conference Coverage Several late-breaking, dramatic results were presented at this final symposium of the meeting. Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, which only a few days earlier had first publicly presented data showing ta
CONFERENCE COVERAGE 2000-07-14 Conference Coverage Several late-breaking, dramatic results were presented at this final symposium of the meeting. Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, which only a few days earlier had first publicly presented data showing ta
CONFERENCE COVERAGE 2000-07-13 Conference Coverage Although there are many reports of neurotoxic effects of amyloid when applied to neurons in culture, the evidence for toxicity in vivo has been less compelling. Of particular surprise has been the finding that most transgenic mice in w
CONFERENCE COVERAGE 2000-07-13 Conference Coverage The centrality of the amyloid hypothesis for AD pathology is evident at this conference not only by the sheer number of papers and posters devoted to it (708 out of a total of 1279, as opposed to 163 for apoE and 152 for presenilin, fo
CONFERENCE COVERAGE 2000-07-13 Conference Coverage The potential contribution of ApoE to AD pathology was cast in a novel light in data presented as a poster today by Huang et al. They were studying the fate of ApoE when expressed by transient transfection in Neuro-2a cells. The ApoE w
CONFERENCE COVERAGE 2000-07-13 Conference Coverage Reported by Walter Lukiw. www.elsevier.com/locate/niad2000 Classical and Alternative Pathways-Neil Cooper. It has been a century since Alzheimer and Bielchowsky reported senile plaques (SP) in AD brain, but it was only relatively rece
