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PAPER Mahul-Mellier AL, Altay MF, Burtsche J, Maharjan N, Ait-Bouziad N, Chiki A, Vingill S, Wade-Martins R, Holton J, Strand C, Haikal C, Li JY, Hamelin R, Croisier M, Knott G, Mairet-Coello G, Weerens L, Michel A, Downey P, Citron M, Lashuel HA
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Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease
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Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s Dementia
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Optogenetic Targeting of Astrocytes Restores Sleep-Dependent Brain Rhythm Function and Slows Alzheimer's Disease
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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease
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Tau seeds translocate across the cell membrane to initiate aggregation
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The Foundational data initiative for Parkinson’s disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism
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Aducanumab
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Apolipoprotein E-1 Harrisburg, a mutation in the receptor binding domain, that is dominant for dysbetalipoproteinemia results in defective ligand-receptor interactions
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ApoE3-Freiburg and apoE4-Freiburg are two genetic apoE variants which are caused by exchanges of uncharged amino acids and do not appear to be associated with lipid disorders or heart disease. Abstract
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Tanycytes are degraded in Alzheimer’s Disease, disrupting the brain-to-blood efflux of Tau
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Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
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