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Other Alzforum’s Papers database contains a list of citations focused on Alzheimer’s disease and related neurodegenerative disorders. The database is updated weekly, with additions announced in Alzforum’s “Papers of the Week.” Alzforum started the database in 1
Other Q: Why is this paper, which was just published, not in the database? A: There is usually a delay between when a paper is published online and when it is entered in PubMed. See also our selection criteria in the Methods page. Q: Can I get the full text of
Other The PubMed database is searched nightly, using a broad range of terms as keyword searches. Alzforum curators screen the abstracts and select papers based on their perceived interest to Alzheimer’s disease researchers. All papers directly related to Alzhei
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Other 1. Is there a “burden of proof” for inclusion? All variants in included genes (currently APP, PSEN1, PSEN2, MAPT, TREM2) are eligible for inclusion, whether they were reported in a peer-reviewed publication, a meeting abstract, a review, or by personal c
Other This database is a repository of genetic variants in genes linked to Alzheimer’s disease (AD). Currently, it includes the three genes (APP, PSEN1, PSEN2) associated with autosomal-dominant AD, plus three genes (APOE, MAPT, and TREM2) with genetic associat
Other Association A genetic association indicates a correlation between a phenotype and a DNA variant. Within this database, associations between a variant and disease are reported based on the study investigators’ criteria for statistical significance, general
Other The Alzforum Mutations database aggregates information about genetic variants reported in the literature. This database focuses on a subset of genes implicated in Alzheimer’s disease. We started out by curating variants in genes associated with autosomal-
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Other As the pace of ascertaining genetic data accelerates and the volume of data grows, researchers face the challenge of understanding the impact of observed genetic variability. Is a given sequence variant neutral, protective, or pathogenic? Together with ot
Other 1. How do I use this database? HEX is designed to provide genetic variability data on a phenotypically characterized set of individuals; specifically, people who have aged without neurodegeneration. For example, a researcher may want to consult HEX if (s)
Other 3' 3', pronounced 3 prime, refers to the third carbon of the sugar rings that form the DNA backbone. The 3' end is the end of the DNA that terminates at the hydroxyl group attached to the third carbon of the sugar ring. DNA sequences are wr
Other Sample Selection and Demographics HEX Version 1.0 includes DNA from 468 individuals categorized as cognitively and neuropathologically healthy. DNA was extracted from brain tissue obtained from several UK and US brain banks, including the Thomas Willis Ox
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Other AlzBiomarker version 1.0 was released December 2015 and meta-analysis results of the initial dataset have been published (Olsson et al., 2016). Version 1.1 was released April 2016 adding neurogranin data and analyses. Version 1.2 was released June 2016 a
