346013 RESULTS
COMMENT By showing that the maternal X-chromosome (Xm) affects cognition in female mice, this study highlights that sex differences in aging cognition could be partly explained by skewed inactivation of the X-chromosome toward Xm. Next steps would be to assess wh
RESEARCH NEWS 2025-02-07 Research News In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in these cells restores their capacity to e
COMMENT This study contributes to a growing body of research on the role of microglial lipid metabolism in Alzheimer’s disease. Important studies from the labs of Tony Wyss-Coray, Li-Huei Tsai, Mathew Blurton-Jones, Gaurav Chopra, Erik Musiek, and many others sho
COMMENT This study investigates the role of the protein FIT2, a key protein in lipid droplet biogenesis, in LD accumulation within microglia and BAMs in an AD mouse model. They show that LDs accumulate with age and AD progression in the two cell types in the CNS
GRANT Friday, February 7, 2025- 2:30pm American Federation for Aging Research (AFAR) Each scholarship is $5,000. No indirect costs or overhead are allowed. April 15, 2025. https://www.afar.org/grants/afar-scholarships 16 Apr 2025
COMMENT Although the sequestering of lipids within intracellular lipid droplets protects against lipid oxidation, excess lipid droplet accumulation is associated with aging and disease. In AD, microglia accumulate excess lipid droplets, which leads to reduced fun
University of Colorado Anschutz Medical Campus
GRANT Friday, February 7, 2025- 2:15pm Glenn Foundation for Medical Research (GFMR), American Federation for Aging Research (AFAR) Up to two three-year awards will be made in 2025. Each award is for $525,000 payable in annual installments of $175,000 per year,
COMMENT Reducing microglial lipid load enhances Aβ phagocytosis in an Alzheimer’s disease mouse model Wu and co-authors investigate the role of lipid-droplet-accumulating microglia (LDAM) and border-associated macrophages (BAMs) in an APP-KI model, which harbors
PAPER Zazo Seco C, Castells-Nobau A, Joo SH, Schraders M, Foo JN, van der Voet M, Velan SS, Nijhof B, Oostrik J, de Vrieze E, Katana R, Mansoor A, Huynen M, Szklarczyk R, Oti M, Tranebjærg L, van Wijk E, Scheffer-de Gooyert JM, Siddique S, Baets J, de Jonghe P, Kazmi SA, Sadananthan SA, van de Warrenburg BP, Khor CC, Göpfert MC, Qamar R, Schenck A, Kremer H, Siddiqi S
CONFERENCE 2025-07-17 00:00:00-2025-07-17 00:00:00 Dublin, Ireland 17 July 2025 View Conference Website 0
CONFERENCE 2025-04-25 00:00:00-2025-05-02 00:00:00 Miami, Florida and Online 25 April – 02 May 2025 View Conference Website 0
CONFERENCE 2025-10-07 00:00:00-2025-10-10 00:00:00 07 – 10 October 2025 View Conference Website 0
PAPER Goh VJ, Tan JS, Tan BC, Seow C, Ong WY, Lim YC, Sun L, Ghosh S, Silver DL
PAPER Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL
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