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c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.

J Neurosci. 2001 Sep 1;21(17):6597-607. PubMed.

PAPER Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL

Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8. PubMed.

PAPER Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10863-8. PubMed.

PAPER Cinar HN, Sweet KL, Hosemann KE, Earley K, Newman AP

The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate.

Dev Biol. 2001 Sep 1;237(1):173-82. PubMed.

PAPER Yip CM, Elton EA, Darabie AA, Morrison MR, McLaurin J

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

J Mol Biol. 2001 Aug 24;311(4):723-34. PubMed.

PAPER Lue LF, Walker DG, Brachova L, Beach TG, Rogers J, Schmidt AM, Stern DM, Yan SD

Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism.

Exp Neurol. 2001 Sep;171(1):29-45. PubMed.

PAPER Kurt MA, Davies DC, Kidd M, Duff K, Rolph SC, Jennings KH, Howlett DR

Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.

Exp Neurol. 2001 Sep;171(1):59-71. PubMed.

PAPER Fahnestock M, Michalski B, Xu B, Coughlin MD

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease.

Mol Cell Neurosci. 2001 Aug;18(2):210-20. PubMed.

PAPER Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

J Med Chem. 2001 Aug 30;44(18):2865-8. PubMed.

PAPER Paganelli AR, Ocaña OH, Prat MI, Franco PG, López SL, Morelli L, Adamo AM, Riccomagno MM, Matsubara E, Shoji M, Affranchino JL, Castaño EM, Carrasco AE

The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis.

Mech Dev. 2001 Sep;107(1-2):119-31. PubMed.

PAPER Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.

EMBO Rep. 2001 Sep;2(9):835-41. PubMed.

PAPER Esler WP, Wolfe MS

A portrait of Alzheimer secretases--new features and familiar faces.

Science. 2001 Aug 24;293(5534):1449-54. PubMed.

PAPER Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

Science. 2001 Aug 24;293(5534):1487-91. PubMed.

PAPER Götz J, Chen F, van Dorpe J, Nitsch RM

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.

Science. 2001 Aug 24;293(5534):1491-5. PubMed.

PAPER Cedazo-Mínguez A, Cowburn RF

Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione.

FEBS Lett. 2001 Aug 24;504(1-2):45-9. PubMed.