Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. One of the most important papers of 2001. Along with Lewis, et al.,
    this paper demonstrated a link between Aβ and tau, and importantly
    showed that hyperphosphorylation and aggregation of tau is precipitated
    by Aβ.

    View all comments by Dominic Walsh

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Finally United? Aβ Found to Influence Tangle Formation
  2. Honolulu: The Missing Link? Tau Mediates Aβ Toxicity at Synapse
  3. San Diego: Pilin’ on the Pyro, Aβ Going Rogue
  4. Like DLB, Like AD—Do Oligomers Stir Up the Trouble?
  5. St. Moritz: Part 5. Vaccine, Microglia, NGF News Fill in Neuroimmunology Picture

Webinars

  1. Intraneuronal Aβ: Was It APP All Along?
  2. Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore?

Research Timeline Event

  1. Aβ fibrils accelerate tangle formation in mice