Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 2020 May;19(5):422-433. PubMed.
AlzBiomarker Database
Meta-Analysis
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| tau-p181 (Plasma) |
AD- biomarker-pos (126) |
19.2 ± 9.4 pg/mL |
SIMOA; Other/Not Specified; In-house |
|
| tau-p181 (Plasma) |
AD- biomarker-pos (33) |
24.9 ± 7.8 pg/mL |
SIMOA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| tau-p181 (Plasma) |
CTRL- biomarker-neg (113) |
10 ± 3.3 pg/mL |
SIMOA; Other/Not Specified; In-house |
|
| tau-p181 (Plasma) |
CTRL- biomarker-neg (337) |
9.4 ± 6 pg/mL |
SIMOA; Other/Not Specified; In-house |
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