Hulstaert F, Blennow K, Ivanoiu A, Schoonderwaldt HC, Riemenschneider M, De Deyn PP, Bancher C, Cras P, Wiltfang J, Mehta PD, Iqbal K, Pottel H, Vanmechelen E, Vanderstichele H. Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF. Neurology. 1999 May 12;52(8):1555-62. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- FTD vs AD : Aβ42 (CSF)
- NPH vs AD : Aβ42 (CSF)
- VaD vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- FTD vs AD : tau-total (CSF)
- NPH vs AD : tau-total (CSF)
- VaD vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (150) |
521.7 ± 197.4 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- Other Controls (100) |
873.6 ± 292.5 pg/mL § |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
FTD (11) |
726.8 ± 278.4 pg/mL § |
ELISA; Innotest; Innogenetics |
1994 |
| Aβ42 (CSF) |
NPH (20) |
605.4 ± 321.8 pg/mL § |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
VaD (33) |
610.7 ± 220.3 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
| tau-total (CSF) |
AD (150) |
520.1 ± 321.5 pg/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- Other Controls (100) |
228.5 ± 149.1 pg/mL § |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
FTD (11) |
324.9 ± 191.4 pg/mL § |
ELISA; Innotest; Innogenetics |
1994 |
| tau-total (CSF) |
NPH (20) |
243.2 ± 244.7 pg/mL § |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
VaD (33) |
326.5 ± 275.7 pg/mL § |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
§ Data supplied to Alzforum by author
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