sAPP α (2B3)
IBL
monoclonal
IgG2b
Mouse
(lyophilized, BSA, PBS, azide, purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide in portion of C-terminus of Human sAPPα(D A E F R H D S G Y E V H H Q K)
detects sAPPα; no cross with sAPPβ or full-length APP
-
sAPPß (swedish type) (6A1)
IBL
monoclonal
IgG3
Mouse
(supernatant, protein-A purified, BSA, PBS, azide, lyophilized)
-
Human
immunogen = synthetic peptide of the C-terminal part of human sAPPß-sw (I S E V N L)
specific for sAPPβ-sw type cleaved by β-secretase; no cross with sAPPβ-sw of wild type and the full length APP of both Swedish and wildtypes
-
APP pan
Leinco Technologies
polyclonal
Goat
(lyophilized, PBS, trehalose, no preservative, affinity purified)
-
Human
immunogen = SF21-derived + 1 frameshift mutant of APP695
APP pan
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, azide, affinity purified)
-
Porcine, Rabbit, Chicken, Human, Hamster, Mouse, Rat
immunogen = peptide seq. corresp. to aa653-662 of human amyloid A4 protein precursor (APP)
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, KPBS, azide, affinity purified)
-
Human
immunogen = Beta amyloid peptide D-A-E-F-R-H-D-S-G-Y-E-V-H-H conjugated to KLH using maleimide. The sequence corresponds to aa 1-14 of human beta amyloid.
AβPP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, antisera, azide)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa residues G L M V G G V V
AβPP
-
AβPP (J4H9)
LifeSpan Biosciences, Inc.
monoclonal
IgG2b , κ
Rabbit
(liquid, PBS, azide)
-
Human
immunogen = APP antibody was raised against recombinant human APP (18-289aa) purified from E. coli
APP
-
AβPP phosThr668
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, azide, glycerol, affinity purified)
-
Human
immunogen = synthetic peptide surrounding amino acid Thr 668 of human APP
AβPP
-
AβPP
LifeSpan Biosciences, Inc.
monoclonal
IgG2a
Mouse
(liquid, PBS, azide, protein A purified)
-
Human, Mouse, Rat
immunogen = Ni-NTA purified truncated recombinant APP expressed in E. coli strain BL21 (DE3)
truncated APP recombinant protein (WB), human APP recombinant protein (ELISA), human Alzheimer brain tissue (IHC)
-
AβPP phos Thr668
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)
-
Human, Mouse, Rat
immunogen = synthetic phosphopeptide corresp. to residues surrounding Thr668 of human APP695 (KLH coupled)
APP when phos at Thr668
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG2a , κ
Mouse
(liquid, IgG fract.)
-
Human
immunogen = synthetic peptide derived from the N-terminal region of human amyloid-b
APP (125kDa, mature and 110kDa immature); recognizes both the b'-cleavage-derived N-terminal ectodomain of APP (sAPPb') and the a-cleavage-derived N-terminal ectodomain of APP (sAPPa)
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG2b
Mouse
(liquid, PBS, no preservative, protein A purified)
-
Human
immunogen = aa17-24 of beta amyloid
reacts with aa17-24 of human amyloid beta peptide (abnormally processed isoforms and precursor forms)
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, azide, affinity purified)
-
Human
immunogen = 30 aa synthetic peptide derived from the full length (1-43aa) β-Amyloid peptide
specific for the 4-5kD β-Amyloid peptide derived by cleavage from the β--Amyloid precursor protein
-
AβPP
Autogen Bioclear
polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
-
Human
immunogen = synthetic peptide corresp. to a protein sequence derived from N-terminus of human Amyloid Beta
recognizes human Amyloid Beta
-
AβPP (33D3)
LifeSpan Biosciences, Inc.
monoclonal
Mouse
(liquid, PBS, azide, protein G purified)
-
Human
immunogen = synthetic peptide corresp. to aa residues 1-16 of Aβ (β-amyloid) peptide
reacts with human Aβ peptide; epitope lies within aa residues 3-8 of β-amyloid (Aβ) peptide
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, no preservative, affinity purified)
-
Human
immunogen = synthetic peptide corresp. to aa1-40 of human β-Amyloid
β-Amyloid [1-40] in the region from aa 15-30; no blocking activity with β-Amyloid [1-12], whereas the peptides β-Amyloid [14-35], β-Amyloid [15-28] and β-Amyloid [17-30] were all able to block antibody activity as well as β-Amyloid [1-40]
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, azide, BSA, glycerol, affinity purified)
-
Human
immunogen = synthetic peptide consisting of 6 aa of human β1-42 within to the C-terminal, conj. to KLH
β-amyloid 42; minimal cross reactivity with β-amyloid 40
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgY
Chicken
(liquid, Tris, azide, glycerol, purified)
-
Human
immunogen = synthetic peptide corresp. to aa25-35 (NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH) near the C-terminal of beta-Amyloid peptide (BSA coupled)
recognizes beta-Amyloid peptide aa 25-35
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgY
Chicken
(liquid, TBS, azide)
-
Bovine, Dog, Rabbit, Chicken, Zebra fish, Sheep, Pig, Human, Monkey, Guinea Pig, Hamster, Mouse, Rat, Xenopus, Cynomolgus
immunogen = synthetic peptide: G S N K G A I I G L M, corresp. to aa25-35 of human β-amyloid
recognizes β-
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, unpurified serum, azide, glycerol)
-
Human
immunogen = synthetic peptide consisting of 6aa of human β1-42 within to the C-terminal, conj. to KLH
β-amyloid 42; minimal cross reactivity with β-amyloid 40
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgY
Chicken
(liquid, Tris, glycerol, azide)
-
Avian (various), Human
immunogen = synthetic peptide corresp. to aa12-28 (NH2-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH) near the C-terminal of Beta-Amyloid peptide (BSA coupled)
recognizes β-Amyloid peptide
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgY
Chicken
(liquid, TBS, azide)
-
Bovine, Dog, Rabbit, Chicken, Zebra fish, Sheep, Pig, Human, Monkey, Guinea Pig, Hamster, Mouse, Rat, Xenopus, Cynomolgus
immunogen = synthetic peptide: V H H Q K L V F F A E D V G S N K , corresp. to C- terminal aa12-28 of human β-amyloid, conj. to BSA
recognizes β-amyloid, peptide 12
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide from N-terminus of human APP
recognizes amyloid precursor protein
-
AβPP
Autogen Bioclear
polyclonal
IgG
Rabbit
(lyophilized, PBS, azide, affinity purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa32-40 of beta-Amyloid conjugated to KLH
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, glycerol, BSA, thimerosal, affinity purified)
-
Human
immunogen = synthetic peptide mapping to the N-terminus of human beta-amyloid
detects 4-5 kDa human beta-Amyloid
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, glycerol, BSA, thimerosal, affinity purified)
-
Chicken, Human, Monkey, Mouse, Rat
-
APP
-
AβPP (33D3)
LifeSpan Biosciences, Inc.
monoclonal
IgG2b
Mouse
(liquid, PBS, no preservative, protein A purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa residues 17-24 of Aβ (β-amyloid) peptide
Aβ
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(lyophilized, unpurified serum)
-
Human, Mouse, Rat
immunogen = synthetic peptide as a part of Amyloid beta A4 protein
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)
-
Human, Monkey, Mouse, Rat
immunogen = peptide corresp. to residues surrounding Thr668 of human APP695
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
-
Human
immunogen = synthetic peptide corresp. to the new C-terminus of caspase-cleaved amyloid precursor protein
recognizes caspase-generated neo epitope of APP
-
APP
LifeSpan Biosciences, Inc.
polyclonal
Rabbit
(DEAE-column chromatography)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa 737-751 of human amyloid precursor protein, seq. corresponds to aa 85-99 of the C99 fragment
recognizes both intact APP and the C99 fragment generated by Beta-secretase
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, neat serum, unpurified)
-
Yeast, Human
immunogen = synthetic molecular mimic of soluble oligomers
recognizes human β-amyloid, oligomer A11; recognizes all types of amyloid oligomers
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
Rabbit
(liquid, PBS, no preservative, affinity purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa1-40 of Aβ (β-amyloid) peptide
recognizes the sequence of Aβ [1-40] in the region from aa 15-30
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, serum, unpurified, azide)
-
Human
immunogen = C-terminal synthetic peptide (human) conjugated to KLH
reacts with Aβ [1-40] of amyloid plaques in AD brains
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
-
Human
-
-
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(lyophilized, serum, unpurified)
-
Mouse, Rat
immunogen = synthetic peptide (H M N V Q N G W K E S D P S G T K T C, aa: 44-62) as part of mouse APP isoform A conj. to the immunogenic protein blue carrier protein
APP
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1 , κ
Mouse
(liquid, PBS, azide, purified)
-
Human
immunogen = 28 aa synthetic peptide derived from the β-amyloid peptide
reacts with the 4-5kD b-amyloid peptide (βAP); high concentrations of antibody will also react with A-a, B-a and gamma subunits of fibrinogen
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1 , κ
Mouse
(liquid, PBS, azide, purified)
-
Human
immunogen = rh β-APP695
β-APP; recognizes an epitope within the first 200 amino acids in the β-APP N-terminus; react with all 3 forms
-
APP
LifeSpan Biosciences, Inc.
polyclonal
Goat
(unpurified serum)
-
Human
immunogen = peptide to the N-terminal region (aa 44-63) of the APP protein
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Goat
(liquid, azide, unpurified serum)
-
Human
immunogen = synthetic peptide corresp. to the aa seq. 44-63 of human amyloid precursor protein
recognizes amyloid precursor protein (APP), 130 kDa
-
AβPP (1B11F3)
LifeSpan Biosciences, Inc.
monoclonal
IgG2a
Mouse
(liquid, ascites, PBS, azide)
-
Human
immunogen = ni-NTA purified truncated recombinant APP expressed in E. coli strain BL21
APP
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG2a
Mouse
(liquid, PBS, BSA, azide, supernatant, purified)
-
Human
immunogen = human serum amyloid A (APO SAA)
reacts with amyloid A, serum; useful for the detection of AA-type amyloid and for the discrimination from other type of amyloid (AL-type and b2M-amyloid)
-
AβPP (8J263)
LifeSpan Biosciences, Inc.
monoclonal
IgG2a
Mouse
(liquid, supernatant)
-
Human, Rat
immunogen = human serum amyloid A (Apo-SAA)
reacts with AA-type Amyloid depositions
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(PBS, azide, BSA, IgG fract, purified)
-
Human
immunogen = human SAA and helix pomatia haemocyanine
reacts with all known SAA types
-
AβPP (8J262)
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Rabbit
(liquid, PBS, BSA, azide, protein G purified)
-
Human
immunogen = human SAA and helix pomatia hemocyanin
reacts with all known SAA types
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(unpurified serum, no preservative)
-
Human
immunogen = APP, KPI Domain
Amyloid Precursor Protein (APP), KPI Domain
-
AβPP (Y188)
LifeSpan Biosciences, Inc.
monoclonal
IgG
Rabbit
(liquid, Tris-glycine, NaCl, supernatant, azide, glycerol)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to residues in the NPXY motif of human Amyloid Beta A4 precursor (APP)
recognizes APP and its isoforms; not either of the two amyloid beta protein (Abeta4) variants, Abeta 1-40 or Abeta 1-42
-
AβPP phos Thr668
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, BSA, HEPES, NaCl, glycerol)
-
Human, Mouse, Rat
immunogen = synthetic peptide (human) corresp. to residues surrounding Thr668 conj. to KLH
detects different isoforms of endogenous amyloid beta (A4) precursor protein only when phosphorylated at Thr668 (position corresponds to APP695 isoform)
-
APP phos Thr668
LifeSpan Biosciences, Inc.
polyclonal
Rabbit
(liquid, PBS, affinity purified, no preservative, no glycerol)
-
Human, Mouse, Rat
immunogen = synthetic phospho-peptide (KLH coupled) corresp. to residues surrounding Thr668 of human APP695
detects different isoforms of amyloid beta (A4) precursor protein only when phosphorylated at Thr668 (position corresponds to APP695 isoform)
-
AβPP
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(liquid, PBS, azide, protein G purified)
-
Human
immunogen = synthetic peptide corresp. to aa seq. 1-17 of human Amyloid Beta protein
recognizes beta amyloid peptide, which is the major protein component of the amyloid cores in neuritic plaques
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, serum, azide)
-
Human, Monkey
immunogen = synthetic peptide composed of aa292-312 from the KPI domain of human APP
recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP)
-
AβPP (8J259)
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(liquid, PBS, protein G purified)
-
Human
immunogen = synthetic peptide, corresp. to aa1-17 of human β- amyloid
APP
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(unpurified serum, azide)
-
Human, Monkey
immunogen = synthetic peptide composed of aa 292-312 from the KPI domain of human APP
recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of APP
-
APP
LifeSpan Biosciences, Inc.
polyclonal
Rabbit
(liquid, PBS, azide, affinity purified)
-
Human, Mouse
immunogen = 22 aa synthetic peptide derived from the C-terminus of human and mouse beta-amyloid precursor protein (beta-APP)
APP
-
APP
LifeSpan Biosciences, Inc.
polyclonal
Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)
-
Bovine, Human, Rat
immunogen = synthetic peptide (KLH coupled) corresp. to residues at the N-terminus of human β-amyloid peptides
detects total levels of several isoforms of beta-amyloid peptide (Abeta) such as beta-amyloid 40, beta-amyloid 42 and others
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Goat
(liquid, neat serum, azide, delipidation and defibrination)
-
Human
immunogen = synthetic peptide: H M N V Q N G K W D S D P S G T K T C I (aa 44-63) of human APP
APP
-
APP (2Q12)
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(liquid, PBS, azide, purified)
-
Fish (various), Human, Monkey, Mouse, Rat
immunogen = purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein
recognizes a N-terminal epitope on the pre-A4 molecule
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, serum, azide)
-
Human
immunogen = beta-amyloid aa1-42
recognizes the beta amyloid (1-42) peptide
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(liquid, ascites, azide, glycerol, purified)
-
Human, Mouse, Rat
immunogen = human beta Amyloid 1-40 (KLH coupled); Epitope: N-terminus of beta amyloid (1-1 aa of 1-40/42).
beta-Amyloid 1-40/42; localized to the N-terminus of beta amyloid (1-13 aa of 1-40/42/43)
-
AβPP
Autogen Bioclear
polyclonal
IgG
Rabbit
(liquid, PBS, azide, glycerol, affinity purified)
-
Human
immunogen = synthetic phosphopeptide corresp. to aa residues surrounding Ser198 of human APP
APP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, serum, azide)
-
Human
immunogen = beta-amyloid aa1-40
recognizes the beta amyloid (1-40) peptide
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, serum, azide)
-
Human
immunogen = disaggregated paired helical filaments
recognizes NFT and degenerating plaque neurites
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, unpurified serum, azide)
-
Human
immunogen = highly purified antigen
β- amyloid (1-42) peptide
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, unpurified serum)
-
Human
immunogen = highly purified beta amyloid (1-40)antigen
recognizes the beta amyloid (1-40) peptide
-
AβPP frameshift mutant
LifeSpan Biosciences, Inc.
polyclonal
IgG
Goat
(liquid, unpurified serum, azide)
-
Human
immunogen = peptide seq. corresp. to aa339-348 of the C-terminus of APP frameshift mutant
binds to the truncated amyloid precursor protein frameshift mutant
-
AβPP (8J264)
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(liquid, PBS, no preservative, protein A purified)
-
Dog, Chicken, Pig, Human, Monkey, Guinea Pig, Mouse, Rat
immunogen = synthetic peptide: L E V P T D G N A G L L A E P Q I A M F C, corresp. to aa18-38 of human amyloid precursor protein
APP
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG
Mouse
(liquid, ascites, azide)
-
Human, Mouse
immunogen = synthetic peptide corresp. to aa 34-40 of human amyloid bx-40 peptide conj. to KLH
recognizes amyloid bx-40 polypeptide, Mr 4.5kD
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG
Mouse
(liquid, ascites, azide)
-
Human, Mouse
immunogen = synthetic peptide corresp. to aa 36-42 of human amyloid bx-42 peptide conj. to KLH
recognizes amyloid bx-42 polypeptide, Mr 4.5kD
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, azide)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to aa737-751of human APP (C-terminal)
recognizes both intact APP, and also the C99 fragment generated by Beta-secretase. The seq. recognized by this antibody corresponds to amino acids 85-99 of the C99 fragment
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
-
Human, Mouse, Rat
immunogen = synthetic peptide corresp. to N-terminal of human APP
APP
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1
Mouse
(ascites)
-
Human, Rat
immunogen = carboxyl fragment of APP 643-695 / Jonas
reacts with intact full-length Alzheimer precursor protein (APP) and selectively with the cytoplasmic carboxyl fragment of APP 643-695
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, azide, serum)
-
Human
immunogen = synthetic peptide corresp. to aa seq. 1-14 of human Amyloid Beta protein. ( N-terminal)
detects beta amyloid, an 87kDa member of the amyloid precursor protein family
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, unpurified serum, azide)
-
Human
immunogen = synthetic peptide corresp. to aa1-14 (D A E F R H D S G Y E V H H) of human amyloid beta
recognizes aa1-14 of amyloid beta
-
AβPP (BAM01)
Autogen Bioclear
monoclonal
IgG1 , κ
Mouse
(liquid, supernatant, azide)
-
Human
immunogen = synthetic peptide: S G Y E V H H Q K L, corresp. to aa660-669 of human APP (which is the same as aa8-17 of the mature amyloid protein)
AβPP
-
AβPP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
-
Human
immunogen = synthetic peptide from aa 8-17 of human amyloid beta-protein
APP
-
APP
LifeSpan Biosciences, Inc.
monoclonal
IgG1 , κ
Mouse
(supernatant, azide)
-
Human, Mouse
immunogen = synthetic peptide corresp. to residues 8-17 (S G Y E V H H Q K L) of the amyloid β-protein/amyloid A4 which is the same as aa 660-669 of human amyloid A4/amyloid β protein precursor
4-5kD peptide derived from the amyloid β-precursor protein
-
APP
LifeSpan Biosciences, Inc.
polyclonal
IgG
Rabbit
(unpurified serum, azide)
-
Human, Monkey
immunogen = synthetic peptide from C-terminus of APP
recognizes an epitope at the C-terminus of APP
-