Software Flaw Casts Doubt on Past Task fMRI Studies
In a validation study, three common software packages produced excessive false positives, but initial stories about previous suspect data might have been overblown.
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Mutant Presenilin Skews Calcium Homeostasis by Chomping on ER Sensor
AD-linked mutations in presenilin 1 increase the enzyme’s cleavage of STIM1a endoplasmic reticulum calcium receptor, reducing Ca2+ influx into neurons and destabilizing dendritic spines. Researchers proposed targeting the pathway as a therapy.
ApoE Variants Modulate Astrocyte Appetite for Synapses
ApoE2 enhances, while ApoE4 reduces, astrocytes’ ability to gobble up synapses. Researchers propose this is one way the apolipoprotein modulates AD risk.
New Target for Tauopathies? Blocking Nuak1 Could Reduce Tau Build-Up
The kinase prevents tau degradation, raising levels and kicking off hyperphosphorylation.
5,000 Down, 95,000 to Go: U.K. Biobank Releases First Brain-Imaging Data
The largest brain-imaging project in history has sliced and diced data from the first 5 percent of its cohort. Neurodegeneration scientists deplore the lack of AD biomarkers.
Could Bacterial Amyloid Trigger Parkinson’s Pathology?
In aging rats, the presence of bacterial amyloid in the gut accelerated the formation of α-synuclein aggregates in brain.
Lack of BIN1 Sows Tau Trouble for Neurons
When the brain is starved of BIN1, endocytosis goes into overdrive. Vesicles gulp more tau aggregates into neurons, feeding their spread.
Are Cholinergic Neurons “Patient Zero” of Alzheimer’s Disease?
Drawing on longitudinal ADNI data, a new study suggests that the degeneration of cholinergic neurons in the basal forebrain kicks off the neurodegenerative cascade of AD.
In NFL Players, Brain Inflammation May Persist Years After Head Trauma
PET scans detect activated glial cells in current and recently retired professional football players up to 21 years after their last concussion.
Dearth of Water Channels a Sign of ‘Glymphatic’ Breakdown in Alzheimer’s?
Less aquaporin-4 in astrocytes surrounding blood vessels suggests impaired clearance of Aβ in people with AD.
Inflammation Helps Microglia Clear Amyloid from AD Brains
Researchers at SfN 2016 proposed dialing up the immune response in Alzheimer’s brains to enhance phagocytosis.
In Welders, Parkinsonism Caused by Exposure to Manganese Progresses
Parkinsonian symptoms in welders exposed to manganese-laden fumes worsen with continued exposure.
Dementia Risk Ticks Up Near Major Roadways
Among older adults living in Ontario, Canada, dementia incidence crept up the closer people lived to busy roads.
ApoE Risk Explained? Isoform-Dependent Boost in APP Expression Uncovered
ApoE isoforms switch on APP expression in human neurons with a potency commensurate with their propensity to increase risk for Alzheimer’s disease, but some researchers question the relevance of this pathway in the human brain.
Building Better Mouse Models for Late-Onset Alzheimer’s
An NIA-sponsored initiative will generate and characterize numerous models carrying late-onset AD genes, advancing the best for preclinical drug testing.
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