In New Study, Diet During Midlife Not Linked to Dementia
Among British civil servants, the quality of their diet did not correlate with their risk of developing dementia cognitive decline over 25 years.
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Deep Blue for Aβ Blood Test?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
More Evidence for Distinct TDP-43 Droplets
Liquid beads of TDP-43 form independently of stress granules and sequester proteins needed for nucleocytoplasmic transport.
Dementia Researchers Commend FDA Crackdown on Supplement Hype
When the agency sent warning letters to 17 companies that falsely advertised cures and preventions for AD, most took down exaggerated claims. But can regulations stay ahead of the market?
Too Little, Too Late? Blood Pressure and Cholesterol Meds Don’t Slow Cognitive Decline in 70s
In people at intermediate risk for cardiovascular disease, the meds had no effect on cognitive decline over six years.
Does High Iron Push a Person With Pathology Into Dementia?
How the element relates to neurodegeneration remains unclear.
Alzheimer’s Association Report Argues for Cognitive Screening
Only 16 percent of seniors report being assessed for cognition during yearly checkups. Eighty-two percent think it should be routine.
Paper Alerts: Massive GWAS Studies Published
Researchers publish 14 new AD variants. This includes one near WWOX, a gene that encodes a protein linked to tau and lipid metabolism.
Stress Granules: No Incubator for Inclusions, After All?
Using a new optogenetic model for TDP-43 phase transitions, scientists see the protein aggregate outside, not inside stress granules. The model distinguishes physiological from abnormal phase transition.
Take With a Grain of Salt: Mitigating Aβ Pathology With Sodium Rutin
A flavonoid reportedly spices up oxidative phosphorylation in microglial mitochondria, revving up phagocytosis of amyloid plaques in mouse models. The small study needs independent replication.
Rogue Gene Networks Track with Neurodegeneration Across Diseases
Aberrant gene-expression patterns found to be common to human neurodegenerative disease and animal models. MicroRNA and epigenetic modification may be to blame.
Multi-Gene Score Predicts Cognitive Decline Independently of Brain Imaging
A score based on the combined burden of a person’s Alzheimer’s risk variants correlated with plaques, tangles, cognitive decline, and even non-AD pathology. Are polygenic hazard scores ready for direct-to-consumer marketing?
Single-Cell Profiling Maps Human Microglial Diversity, Flexibility
Human cells show more phenotypic variation than mouse microglia, but the two match up well overall.
Nixing Neuron Receptor Improves Recovery from Stroke, Trauma
Knocking down or blocking the CCR5 receptor with an HIV drug improved motor symptoms and learning and memory in a mouse model of stroke. Recently, researchers in China knocked out this gene in babies using CRISPR.
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