Midlife Pep Does Not Curtail Alzheimer’s Biomarkers
Exercising the brain and body in middle age may not limit progression of Alzheimer’s pathology.
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Dementia Incidence in Britain Dropped, Mostly in Men
Researchers confirm that new cases of dementia are on the wane in the United Kingdom, with the greatest benefits among older men.
Aβ Oligomers Purified from Human Brain
It was not easy, but it got done—and the catch looks nothing like prior synthetic or mouse versions of these species.
On Multiple Marker Analysis, Tangles Track Best With Functional Decline
Scientists match up PET scans of neurofibrillary tangles against Aβ imaging, CSF measures, and cognitive tests to see how biomarkers change relative to function.
Do Platelets Provide a Platform for Aβ Aggregation?
Anti-platelet therapy might treat vascular dementia, researchers suggest.
Blood NfL Looks Good as Progression and Outcome Marker
Levels of neurofilament light in blood and spinal fluid of mice reflected brain pathology and changed with treatment.
No Special Glasses Needed: Three-Dimensional Views of Tau and Aβ in the Brain
Take a three-dimensional tour of the plaques and tangles of mouse and human brains as they develop Alzheimer’s disease-related pathology.
Tau Deepens Cognitive Trouble in Lewy Body Diseases
Researchers report that tau accumulation in the cortex associates with cognitive impairment in people with ongoing synucleinopathy. Aβ is not necessary for this type of tauopathy.
Distinct Roles for Brain and Blood ApoE in Neuron Health?
A mouse that expresses ApoE only in the blood loses synapses in the brain, but appears to learn and remember normally.
Fatty Acid Greases the Wheels for α-Synuclein Multimers
When mixed with arachidonic acid, α-synuclein formed soluble multimers rather than toxic fibrils. Researchers speculate that these multimers represent the physiological norm in synaptic compartments.
ALS Research ‘Gels’ as Studies Tie Disparate Genetic Factors Together
Two labs report that dipeptide repeats derived from C9ORF72 latch onto TDP43, FUS, and other proteins that form liquid organelles. The liquid then gels, retarding cellular functions.
Paper Alert: Verubecestat Preclinical and Phase 1 Data Published
As reported at meetings, Merck’s BACE inhibitor reduced CSF Aβ in animals and people with apparently few side effects. Researchers express optimism for the drug and others in its class.
ALS-FTD Mouse Model Develops Motor Neuron Disease
Mice expressing a mutant version of human UBQLN2 develop TDP-43 pathology in their spinal cords, while losing motor neurons, muscle mass, and muscle innervation of with age.
U.S. Dementia Rates Fall
Evidence from a nationally representative sample suggests a 12-year drop in age-specific risk of dementia.
Pericytes Don’t Go With the Flow—They Change It
The vascular cells, which die off in Alzheimer’s disease, may be crucial for regulating blood supply to the brain.
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