Familial Alzheimer’s Gene Alters Children’s Brains
In children as young as 9 who carry a presenilin 1 mutation, researchers detect subtle functional and structural brain changes.
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Could Genetic Mosaicism in Adult Neurons Precipitate Disease?
New genetic methods make it possible to measure variations in DNA from one brain cell to the next, and to investigate whether these mosaic mutations contribute to disease.
Reelin in Aβ Damage?
Adult mice walk the straight and narrow without reelin, but are more susceptible to Aβ.
New WAVE in Aβ Production—AICD Tempers APP Processing
The intracellular domain of the amyloid precursor protein may alter gene expression to reduce production of Aβ.
Alzheimer’s Transmission Between People? Amyloid Plaques in Hormone Recipients Hint at Prion-like Spread
Decades after getting injections of human growth hormone from brain donors, some people developed amyloid pathology that researchers attribute to transmission of Aβ seeds hidden in the injections.
Electron Microscope Yields Finer Structure of α-Synuclein, Aβ Fibrils
Micro-electron diffraction reveals atomic resolution of β-sheet structure in an α-synuclein crystal, while a close-up of Aβ fibrils surprises with turns shaped like a tilde.
Barriers Between Blood and CSF, Brain Yield to Aβ—Not a Bad Thing?
Mouse studies show the peptide damages the borders between the circulation and central nervous system, but also find that a weakened wall helps clear Aβ from the brain.
C9ORF72 RNA Foci Acquitted of Toxic Charge—in Fruit Flies
Drosophila were just fine, thank you very much, despite carrying the ALS- and FTD-linked repeats in the same intronic context as they occur in people.
New Type of Toxic Tau? Acetylated Form Correlates With Memory Defects
Acetylated tau accumulates in Alzheimer’s disease, and associates with pathology and behavioral measures in mouse models.
Scientists Eye Ocular Movements for Clues to Brain Pathology
Altered responses to visual stimuli could signify the extent of TDP-43 pathology in the brain, researchers predict.
Close Encounters: A New Look at Where APP and BACE1 Meet
Researchers detect liaisons between amyloid precursor protein and β-secretase in Golgi-derived vesicles and recycling endosomes, providing clues to where Aβ could form.
Proposed 2016 Budget Boosts Alzheimer’s Funding By 60 Percent
Lawmakers have earmarked an additional $350 million for Alzheimer’s research, the largest increase in history.
Nicastrin Bounces Bulky Proteins from γ-Secretase
Nicastrin selects substrates for γ–secretase by turning away proteins with large ectodomains.
Bon Appétit: Endogenous Antibodies Prod Microglia to Eat Aβ Deposits
Genetic deletion of white blood cells in an Alzheimer’s mouse model quadrupled plaque load, but restoring peripheral antibodies halved this increase.
Midlife Pep Does Not Curtail Alzheimer’s Biomarkers
Exercising the brain and body in middle age may not limit progression of Alzheimer’s pathology.
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