A Plasma Test for Tangles?
In blood, fragments of tau containing the microtubule binding region could help diagnose dementia due to Alzheimer’s disease.
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By Setting Standards, Experts Aim to Tame a Wild West of AD Blood Tests
An expert panel has laid out performance standards on amyloid tests. Clinical context will dictate accuracy, and online calculators might help.
In Head-to-Head Testing, P-Tau217/Tau217 Comes Out on Top. By a Hair.
The percentage of tau fragments phosphorylated at amino acid 217 best pegged people with brain amyloid or tangles. The ratio’s edge over other markers is slight, though.
Treat Before ‘Aβ Bothers Tau,’ Scientists Say at CTAD
At trials conference, multiple amyloid immunotherapy programs reported greatest cognitive benefits for people whose tau tangle deposition has only just begun.
Using Lecanemab Trial Data to Determine Maintenance Dose
At AD/PD, researchers presented pharmacologic analyses that could help predict antibody effects and select the right dosage to keep plaques at bay.
Gantenerumab Mystery: How Did It Lose Potency in Phase 3?
In the Graduate trials, the anti-amyloid antibody gantenerumab cleared only half as much plaque as it had done in earlier studies. Is formulation or dosing to blame?
How Presenilin Mutations Hobble γ-Secretase Predicts Onset, Progression
A study links 161 PSEN 1 mutations to age of onset and disease progression. Good news for variant calling, and for developing γ-secretase modulators.
Leqembi: The Case for Long-Term Dosing
At AAIC 2024, speakers pointed to worsening biomarkers and cognition after dosing stopped, and linked the protofibrils targeted by lecanemab to neurodegeneration.
NULISA—A New Proteomic Method to Revamp Biomarker Analysis
Alzheimer’s markers are quantifiable in dried plasma, simplifying future diagnoses. With new ultrasensitive assays, hundreds of proteins could be analyzed this way.
That Retrotransposon in TMEM106b: Friend or Foe?
How—or even if—a newly spotted AluYb8 element raises risk of neurodegenerative disease has become a question of intense interest. Centenarians, it seems, are spared.
At the Edge of Spatial Omics, Cellular Response to Amyloid Comes into View
At AAIC, scientists linked Alzheimer’s pathology to the demise of nearby neurons, and implicated plaque-adjacent glia in sparking tau pathology.
CSF Proteomics Hints at How ApoE4 Promotes AD, and How a Drug Hinders It
Pathways of autophagy, ubiquitination, endocytosis, and glycolysis changed in Alzheimer’s. Treatment with the drug atomoxetine normalized some of them.
Among Icelanders, Blood Proteome Predicts Dementia, Parses Role of ApoE4
The plasma concentration of some 300 proteins foretold dementia. Fewer than half of the proteins were connected to Alzheimer’s independently of ApoE.
A Neurologist’s Devotion Puts Familial AD Research Onto New Plane
What has the Alzheimer’s Prevention Initiative accomplished this past year?...
MODEL-AD Probably Has Something for You
The consortium has cranked out dozens of mouse models of late-onset AD for the research community. Strains carry humanized Aβ and tau, and a growing list of risk variants.
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