Plasma P-tau217 Picks Up Plaques, Tangles, Future Decline
In some patients, the blood Aβ42/40 test fell too close to the cutoff for specialists to confidently diagnose AD. Comorbidities, drugs also complicate results. Two CSF tests are FDA-approved.
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Primary Tauopathies Get New PET Ligands
Autopsy data confirm that current tau PET tracers are unsuitable for some primary tauopathies. CryoEM structures help researchers find new ligands for tau and α-synuclein.
Next-Generation Mouse Models: Tau Knock-ins and Human Chimeras
At SfN 2016, researchers debuted new mouse models that may better represent human disease.
Can Extracellular Vesicles Help Diagnose Subtypes of FTD-ALS?
Ratio of 3R/4R tau in extracellular vesicles identified people with behavioral variant FTD and PSP. Vesicle TDP43 identified bvFTD and ALS.
Donanemab Approved in the U.S.
The antibody becomes the second amyloid immunotherapy to receive traditional FDA approval, joining Leqembi.
Head Injury and Parkinsonism—It’s the Tangles, Not the Lewy Bodies
In postmortem analyses of athletes who had repetitive head injuries, neurofibrillary tangles were more common than α-synuclein fibrils in the substantia nigra.
Rubbing Microglia the Right Way? At ADPD, Scientists Showcase New Strategies
Preclinical studies and early phase trials target microglial receptors CD33 and TREM2, and amyloid-stoking ASC specks.
Plasma p-Tau-217 Assays Work Well, But No Home Run for Diagnosis
For a diagnostic test, specificity and sensitivity fall a little shy. Using two cut points might solve the problem.
Blood Tests: Charting the Path to Primary Care
Certain blood biomarker tests can tell that amyloid has built up in a person's brain and that their thinking will decline. What are the challenges ahead before these tests can be rolled out to medical care settings everywhere?
What Happens After Amyloid Plaque Removal? Who Benefits Most?
Clearance triggers improvement in downstream markers of inflammation and neurodegeneration—but not in those who started with high tangle burden. (Clue: women.)
Living Among Us: People Whose Alzheimer’s Is Already Being Prevented
On gantenerumab, some people with dominantly inherited AD mutations remain plaque- and tangle-free, and cognitively healthy, years after their expected age of onset.
Are Alzheimer’s Blood Tests Ready for Primary Care?
Plasma p-tau217/tau217, alone or with Aβ42/40, identified people with amyloid pathology more accurately than did expert clinical assessment.
Implicated in ARIA: Perivascular Macrophages and Microglia
These immune cells spew free radicals and inflammatory cytokines that damage blood vessels, contributing to edema and brain bleeds.
Microglial Epigenetics Hints at How ApoE Toggles Alzheimer’s Risk
When faced with amyloid, ApoE4 microglia crank up pro-inflammatory genes. ApoE2 microglia do the opposite. They quell neuroinflammation via the vitamin D receptor.
A Finger-Prick Test for Alzheimer’s Disease?
Markers for AD can be measured in dried blood. This could greatly simplify diagnosis in far-flung areas. With new ultrasensitive assays, hundreds of proteins could be tested this way.
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