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That β-amyloid plays a central role in the pathogenesis of Alzheimer's disease is doubted by few investigators. However, pinning down the exact contribution amyloid makes has been remarkably difficult to accomplish...
It is likely that a process very reminiscent of that suggested for Aβ formation—fibrillar protein deposition—is to blame for the rare, inherited disorder Familial British Dementia (FBD)...
According to a report in tomorrow's Science, researchers have uncovered a strong candidate for β-secretase, the mystery enzyme that cleaves APP and allows Aβ to be formed in subsequent cleavages...
From today's Journal of Neuroscience comes evidence that intermediate Aβ species could be damaging neurons. Dean Hartley, Dennis Selkoe, and their colleagues report that so-called "protofibrillar" Aβ...
Further evidence that apoE is needed for deposition of the fibrillar form of Aβ in plaques was presented today at the American Neurological Association's annual meeting in Seattle today...
Protein misprocessing and aggregation have been observed in many neurodegenerative diseases, including Alzheimer’s, spongiform encephalopathies, Huntington’s, Parkinson’s and FTDP-17, but it has been difficult...
Writing in the current Nature Neuroscience, Heather Cameron and Ronald D.G. McKay report that they were able to boost the rate of neurogenesis in the hippocampus of aging rats by lowering corticosteroid levels...
In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues provide evidence that under normal circumstances, APP is a critical player in the formation and maintenance of synapses...
In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP...
Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries...
If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems...
In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently...
Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation...
Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...
In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid in Familial British Dementia (FBD)...
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