Studies Point to DNA Difficulties in ALS/FTD
New work implicates changes in chromatin structure and failed DNA repair in neurodegeneration.
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Midlife Peripheral Inflammation May Drive Later Cognitive Decline
A longitudinal study finds that middle-aged people with the highest levels of inflammation markers in their blood succumb to the greatest cognitive decline over the next 20 years.
Single-Cell Profiling Maps Human Microglial Diversity, Flexibility
Human cells show more phenotypic variation than mouse microglia, but the two match up well overall.
Paper Alerts: Massive GWAS Studies Published
Researchers publish 14 new AD variants. This includes one near WWOX, a gene that encodes a protein linked to tau and lipid metabolism.
CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
In Year Three, GAP Trial Network Is Starting to Hum
With three trials and initiatives to boost recruitment, GAP-Net is gaining some traction in the field.
GAP-Net Site Optimization Conference 2019
In Year Three, GAP Trial Network Is Starting to Hum Getting to Go: GAP-Net Sets Sight on Faster Start Three years after the Global Alzheimer’s Platform (GAP) Foundation launched GAP-Net, a standing network of clinical trial sites optimized for Alzheimer’s
Getting to Go: GAP-Net Sets Sight on Faster Start
From central IRBs, certified raters, to local transport: Changes large and small are needed to ramp up drug testing in Alzheimer’s.
NIH Summit Sets Agenda for AD-Related Dementias
Among 20 focus areas, 47 research recommendations cover the gamut from basic science to health disparities.
Randall Bateman Wins Potamkin Prize
Award recognizes his contributions to basic and clinical research.
FDA Panel Rejects Neuronix Brain Stimulation Device
Experts said Phase 3 data did not prove the device could slow AD.
Results from IDEAS Study Published
A majority of amyloid PET scans led physicians to change how they managed a patient’s disease. The effect on later outcomes is yet to be come.
Resetting Brain Rhythms Gives Working Memory a Brief Boost
Transcranial, alternating electrical current restored neuronal synchrony in older people, rejuvenating working memory. For an hour or two.
Familial Alzheimer’s Mutations: Different Mechanisms, Same End Result
A fleet of patient-derived neurons show that while an APP mutation shifts where γ-secretase takes its first bite, PS1 mutations blunt the enzyme’s second cut. Eventually, all mutations drive up the Aβ42:40 ratio.
Amid Brexhaustion, U.K. DRI Marches On, Seeks Innovation Director
Institute to chart new translational research territory.
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