Tracking Onset and Progression of Frontotemporal Dementia
New scales debuted at ICFTD could help clinical trials.
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A Proteomics Dive into Cause of Frontotemporal Dementia
Proteomics and protein-protein interaction research may yield clues to etiology, tracking, and treatment of granulin-related and other forms of FTD/ALS.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
First Round of Awards from Chan Zuckerberg Initiative Announced
The awards total $52 million, divided among 17 early career investigators and nine collaborative science teams.
World Dementia Council Takes Stock of Progress, Challenges
Five years after its creation, the WDC met in London to reflect, articulate next steps, and announce more sharing of BACE trial data.
Microglia Reveal Formidable Complexity, Deep Culpability in AD
Many genes that increase risk for late-onset AD are expressed in microglia, and researchers are going cell by cell to unravel the pathways involved in the immune response to amyloid and tau.
How Immune Cells From Blood Beget Aging in Brain
At SfN, some scientists described how circulating immune cells deliver aging to the mouse hippocampus; others held off parkinsonism by blocking the effects of eotaxin’s rise in blood. Human trials are starting.
When Glial Clocks Fall Out of Sync, Inflammation Ensues
Disrupting circadian clocks in astrocytes and microglia unleashed harmful responses in these glial cells, leading to neuronal damage.
Stem Cell Model Nails Link Between Tauopathy and GABAergic Dysfunction
By marrying iPSCs, human genomic data, and analysis of postmortem tissue, researchers tied loss of GABAergic signaling to tauopathies such as FTD and PSP, but not AD.
Could a Blood Test for Tau Diagnose Alzheimer’s Disease?
An ultrasensitive assay picked up elevated concentrations of N-terminal tau fragments in the blood of people with AD.
2018—A Year in Research
This past year, therapeutic antibodies massively reduced brain amyloid, blood tests came into their own, and systems-based approaches transformed the study of gene expression, glial cells, and selective vulnerability.
GABA-A Receptor Structures Point to Drug Mechanisms
CryoEM helps explain how the inhibitory receptors open and close their ion channels.
Without TREM2, Plaques Grow Fast in Mice, Have Less ApoE
Absent the receptor, microglia ignore Aβ seeds and new plaques, which then absorb little ApoE and stay diffuse.
Deadline to Weigh In on New Biomarker Guidance Approaches
Stakeholders have until February 11 to comment on draft FDA guidance for biomarker qualification.
Invasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei
In neurons derived from FTD patients, microtubules distort the nucleus, warping its normally rounded membrane and disrupting communication with the cytoplasm.
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