New Genetic Variants Associated with Brain Imaging Traits
Using whole-genome sequence analysis, researchers find genetic variants linked to white-matter integrity, and cerebral and hippocampal volume.
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Scanning Top 20 GWAS Hits for Amyloidosis: Slim Pickings
In ADNI, only a handful of variants associate with amyloid PET. Their impact may vary by disease stage.
No Amyloid, No Memory Problem—Even with ApoE4?
In AIBL, memory declines as people with brain amyloid age. Without amyloid, episodic memory keeps steady, even in ApoE4 carriers.
Can Closed-Loop Brain Stimulation Improve Memory?
Researchers improve word recall by jolting the lateral temporal cortex, claiming this counters firing patterns linked to poor memorization.
Are Reversible Amyloids Behind Liquid-Liquid Phase Separation?
Newly found labile cross-β filament structures may mediate multivalent protein interactions among low-complexity domains.
Chan Zuckerberg Initiative Seeks Collaborators for Basic Research in Neurodegeneration
Its Challenge Network seeks to attract new investigators and new ideas to focus on cross-disease cell biology.
Pimavanserin Phase 2 Trial Data Published
First presented at CTAD 2017, results suggest good safety, hint at efficacy for this serotonin-targeted drug.
Citrullination, Anyone? New Gene Implicated in ALS
A variant squelching expression of PAD4 enzyme reportedly drives up ALS risk by reducing aggregation of RNA-binding proteins.
Is Alcohol Abuse a Bigger Dementia Risk Than We Thought?
Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
FUS Helps miRNA Silence Genes. For ALS, What Does It Mean?
Scientists found FUS interacts with Argonaute, miRNAs, and targets mRNAs to quell gene expression.
Antisense Therapy Cuts Huntingtin Protein in CSF by Half
Ionis Pharmaceuticals reported positive top-line data from the Phase 1/2a trial of its ASO.
De Strooper, Goedert, Hardy, Haass Share 2018 Brain Prize
World’s biggest brain research award goes to European leaders on Aβ tau and TREM2.
Big Data Was the Big Theme at Shortened NIH Summit
A winter storm cut the meeting short, but not before attendees learned that viral load correlates with clinical and pathological traits of AD.
So Far, So Good for Parkinson’s Gene Therapy
Voyager Therapeutics announced positive interim results from a small, ongoing Phase 1b trial in people with advanced PD.
New RNA CRISPR Tool Normalizes Tau Splicing
A family of petite, RNA-directed nucleases offers a platform for finessing the transcriptome.
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