High-Dose Aβ and Tau Immunotherapies Complete Initial Safety Tests
Phase 1 clinical data presented at AAIC 2017 suggest few serious adverse events.
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
Stem Cells Rescue Movement in Monkey Model of Parkinson’s
Dopaminergic neurons made from human iPS cells take root in monkey brains and reverse PD-like motor problems. Matching donor and host immune signatures mitigates graft rejection.
Aging Mice are Sharper, Fitter on a High-Fat, Low-Carb Diet
Two new mouse studies show that a ketogenic diet that avoids obesity improves the health of mind and body, increasing median lifespan. Related studies hint at possible benefits for Alzheimer’s disease.
New Tool Profiles mRNA Ends of Specific Cells in Mouse Brain
Engineering mice to express a tagged polyA-binding protein in specific cell types allows researchers to pull out neuronal, astroglial, or microglial mRNAs from the intact brain and examine each cell type′s mix of mRNA 3' ends.
Bloodborne Tau: Foggy Window into the Brain for TBI, Dementia
Tau in the plasma rises after traumatic brain injury, with cognitive decline, and progression to mild cognitive impairment.
FUS Stabilizes Synaptic Protein mRNAs, Dendritic Spines
The RNA-binding protein FUS promotes synthesis of an isoform of SynGAP, a protein that bolsters dendritic spines. Restoring SynGAP expression partially rescued deficits in FUS–deficient mice.
CRISPR Reveals New Suppressors of α-Synuclein Toxicity
New CRISPR screen flags dozens of genes that suppress toxicity of the Parkinson’s protein. Tweaking multiple genes strengthened the protection.
ALS Kin Have More Neuropsychiatric Disease
Relatives of patients who have ALS are more likely to live with neuropsychiatric diseases such as schizophrenia, obsessive-compulsive disorder, and alcoholism.
Gene Expression Map of Human Body Gives Value to Variants
In a massive project analyzing gene expression patterns among 44 human tissues from 449 people, researchers correlated genetic variation with region-specific transcriptomes.
FTD Variant Alters Chromatin, Boosts Expression of TMEM106b
A single-nucleotide polymorphism near the TMEM106b locus boosts expression of the gene, which is linked to frontotemporal dementia.
Sparking the Brain May Enhance Plasticity, Memory
Neuronal plasticity falters with Alzheimer’s disease, but noninvasive stimulation strengthens it. Meanwhile, mini-jolts inside the brain improve face recognition in epilepsy patients.
NIA Seeks Community Input on Alzheimer’s Eureka Prize
The agency’s request for information seeks feedback on the nature and value of the prize. Help shape it!
LipiDiDiet Data Published
Souvenaid missed its primary cognitive endpoint in the two-year trial, but reduced brain atrophy and slowed functional decline.
Brain-Specific Klotho Isoform Fortifies Memory
Expressed in the brains of mice, a secreted form of the anti-aging protein, klotho, protects from an age-related decline in memory.
SOS Signals from Neurons to Astrocytes Muffled in ALS
Signals from neuron EphB1 receptors boost neuroprotective functions in astrocytes. This line of communication appears cut in ALS.
Current Filters
No filters selected